Review of nonsurgical and surgical treatment and the role of insulin-sensitizing agents in the management of infertile women with polycystic ovary syndrome

Acta Obstetricia Et Gynecologica Scandinavica
Ahmed M Saleh, Hala S Khalil

Abstract

To review the nonsurgical and surgical treatment and the role of insulin-sensitizing agents in the management of anovulatory infertile women with polycystic ovary syndrome (PCOS). The search term of subfertile women with anovulation and PCOS was used for identification of randomized controlled trials. Nonrandomized controlled studies were identified through computer MEDLINE and EMBASE searches for the years 1980-2002. For obese PCOS women weight loss of > 5% of pretreatment weight restores menstrual regularity in 89%, of whom 30% achieved spontaneous pregnancy. It was estimated that 75-80% of anovulatory PCOS women will respond to clomiphene citrate (CC) and 35-50% will achieve pregnancy. For CC-resistant PCOS women (20-25%), CC + metformin (1.5 g/day) for 3-6 months has a 70% chance of restoration of regular menses and ovulation, and a 23% chance of pregnancy. Laparoscopic ovarian drilling (LOD) can be offered to CC-resistant PCOS women. There was no statistically significant difference in the ovulation rate following LOD with electrocoagulation and laser [83% vs. 77.5%; odds ratio (OR) 1.4; 95% CI 0.9-2.1], while there was a significantly higher cumulative pregnancy rate at 12 months after surgery (65% vs. 54.5%; OR 1.5; 95% ...Continue Reading

References

Jul 1, 1977·Fertility and Sterility·J GarciaA C Wentz
Jan 1, 1991·British Journal of Obstetrics and Gynaecology·G KovacsS Phillips
Mar 1, 1989·Annals of Internal Medicine·R Barnes, R L Rosenfield
Jan 1, 1989·Geburtshilfe und Frauenheilkunde·J HuberJ Spona
Jan 1, 1989·The Journal of Clinical Endocrinology and Metabolism·R PasqualiL Barbara
Apr 16, 1988·Lancet·D W PolsonS Franks
Feb 1, 1989·Fertility and Sterility·J F Daniell, W Miller
Feb 1, 1987·American Journal of Obstetrics and Gynecology·E Greenblatt, R F Casper
Sep 1, 1987·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·M G Hull
Mar 3, 1988·The New England Journal of Medicine·T J McKenna
Apr 1, 1970·The Journal of Clinical Endocrinology and Metabolism·S S YenJ Rankin
Aug 1, 1983·The Journal of Clinical Endocrinology and Metabolism·R J ChangS A Kaplan
Jan 1, 1980·The Journal of Clinical Endocrinology and Metabolism·G A BurghenA E Kitabchi
Sep 28, 1995·The New England Journal of Medicine·S Franks
Feb 29, 1996·The New England Journal of Medicine·C J Bailey, R C Turner
Aug 1, 1996·The Journal of the American Association of Gynecologic Laparoscopists·R N Merchant
Nov 1, 1996·The Journal of the American Association of Gynecologic Laparoscopists·M A Pelosi, M A Pelosi
Apr 16, 1998·European Journal of Endocrinology·E Diamanti-KandarakisA Bergiele
Jun 25, 1998·The New England Journal of Medicine·J E NestlerR Pasquali
Aug 26, 1998·The American Journal of Medicine·T C Fagan, P C Deedwania

❮ Previous
Next ❯

Citations

Oct 1, 2005·Archives of Gynecology and Obstetrics·Nikiforos BallianGregory A Kaltsas
Mar 19, 2013·Food & Nutrition Research·Elisabet ForsumInga Thorsdottir
May 9, 2008·Gynécologie, obstétrique & fertilité·S Le GoffG Bader
Jul 29, 2005·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Antonio Pedro AugeJosé Mendes Aldrighi
Jun 1, 2006·Current Opinion in Obstetrics & Gynecology·Cihat Unlu, Cem S Atabekoglu
May 15, 2007·Current Opinion in Obstetrics & Gynecology·Souzan Kafy, Togas Tulandi
Jan 5, 2006·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Francesca CristelloAndrea Riccardo Genazzani
Sep 4, 2007·Human Reproduction Update·Etelka MollMadelon van Wely
Aug 8, 2007·Journal of the Cardiometabolic Syndrome·Khurshid A KhanL Romayne Kurukulasuriya
Jan 5, 2006·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Hiroshi HayashiMitsuyoshi Urashima
Nov 5, 2020·International Journal of Molecular Sciences·Kok-Min SeowPeng-Hui Wang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Fertility and Sterility
Practice Committee of the American Society for Reproductive Medicine
The Journal of Obstetrics and Gynaecology Research
Noraihan Mohd NordinEdwin Malcolm Symonds
International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
N O TurhanI Inegöl
© 2022 Meta ULC. All rights reserved