Review of osteoporosis pharmacotherapy for geriatric patients

The American Journal of Geriatric Pharmacotherapy
Brian J GatesErin K Dobbins

Abstract

Fractures are a significant problem in geriatric patients, and understanding the evidence for benefit and possible harm of osteoporosis treatments is critical to appropriate management of this patient population. The purpose of this article was to review the evidence and treatment considerations related to use of the approved osteoporosis treatments in the United States across the continuum of ages in the geriatric population. MEDLINE and the Web of Science were searched to find English-language articles published from 2000 through July 2009. Search terms included: practice guideline, osteoporosis, calcium, vitamin D, pharmacoeconomics, ethnicity, and treatment. The generic names of each of the osteoporosis treatments approved in the United States were searched to find relevant clinical trials and randomized controlled trials (RCTs). Pivotal trials that included fracture data or focused specifically on elderly patients (> or = 60 years of age) were selected. Bibliographies in the identified articles were searched for additional articles, and the prescribing information for each of the approved treatments was reviewed. Many osteoporosis studies have a mean patient age >60 years, but data for older patients are limited. Subanalys...Continue Reading

References

Aug 1, 1991·The Journal of Clinical Investigation·K D FineJ S Fordtran
Dec 1, 1990·Journal of the American College of Nutrition·J A HarveyC Y Pak
Apr 27, 1989·The New England Journal of Medicine·L R SchillerJ S Fordtran
Dec 1, 1994·Journal of the American College of Nutrition·J Moon
Nov 3, 1998·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A A IsmailA J Silman
Jun 15, 1999·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·R P HeaneyM J Barger-Lux
Oct 8, 1999·Seizure : the Journal of the British Epilepsy Association·L J StephenM J Brodie
Nov 7, 1999·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·R D WasnichA J Yates
Feb 9, 2000·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J ReginsterR Eastell
Sep 1, 2000·Journal of the American Geriatrics Society·E W GreggC J Caspersen
Sep 19, 2000·American Journal of Obstetrics and Gynecology·L Weinstein, B Ullery
Feb 15, 2001·The New England Journal of Medicine·M R McClungUNKNOWN Hip Intervention Program Study Group
Feb 15, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy
Jul 4, 2001·JAMA : the Journal of the American Medical Association·S M CadaretteUNKNOWN Canadian Multicentre Osteoporosis Study
Oct 3, 2001·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·L K KohUNKNOWN Osteoporosis Self-Assessment Tool for Asians (OSTA) Research Group
Nov 22, 2001·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M EspallarguesA Granados
May 16, 2002·Neurology·G FarhatG El-Hajj Fuleihan
Aug 16, 2002·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·T P van StaaC Cooper
Apr 18, 2003·Endocrinology and Metabolism Clinics of North America·Ego Seeman
Jun 27, 2003·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·D M KadoS R Cummings
Sep 23, 2003·The New England Journal of Medicine·Dennis M BlackUNKNOWN PaTH Study Investigators
Oct 2, 2003·JAMA : the Journal of the American Medical Association·Jane A CauleyUNKNOWN Women's Health Initiative Investigators
Oct 14, 2003·Journal of Applied Physiology·Ego Seeman
Nov 1, 2003·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A KanisB Jonsson
Nov 5, 2003·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·John A KanisBengt Jonsson
Apr 29, 2004·JAMA : the Journal of the American Medical Association·Heike A Bischoff-FerrariJohn B Wong
May 5, 2004·Epilepsy & Behavior : E&B·Marc K Drezner
Jul 3, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Charles H ChesnutUNKNOWN Oral Ibandronate Osteoporosis Vertebral Fracture Trial in North America and Europe (BONE)
May 12, 2005·JAMA : the Journal of the American Medical Association·Heike A Bischoff-FerrariBess Dawson-Hughes
Jul 8, 2005·The New England Journal of Medicine·Brian G M DurieJohn Crowley
Aug 2, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Charles H ChesnutLinda Mindeholm
Nov 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Aristotle BamiasMeletios A Dimopoulos
May 11, 2006·Proceedings of the National Academy of Sciences of the United States of America·Kathryn L KavanaghUdo Oppermann

❮ Previous
Next ❯

Citations

Mar 25, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C W RheeB J Park
Jun 21, 2012·Zeitschrift für Gerontologie und Geriatrie·M GoschP Pietschmann
May 18, 2013·Archives of Orthopaedic and Trauma Surgery·M GoschM Blauth
Mar 4, 2011·Biogerontology·Elaine Emmerson, Matthew J Hardman
Sep 13, 2013·Aging Clinical and Experimental Research·Francisco José Tarazona-Santabalbina, Luis Aguilella-Fernández
Dec 12, 2012·Omics : a Journal of Integrative Biology·Karen Rojo VenegasMiguel Angel Calleja Hernández
Jul 16, 2011·International Journal of Biomedical Imaging·Maryam RahmaniMadjid Shakiba
Apr 10, 2014·Clinical Medicine : Journal of the Royal College of Physicians of London·Tara Coughlan, Frances Dockery
Sep 4, 2014·The New England Journal of Medicine·Jörg SchilcherKarl Michaëlsson
Nov 30, 2014·Best Practice & Research. Clinical Endocrinology & Metabolism·Francesca Marini, Maria Luisa Brandi
Jan 19, 2012·Acta Odontologica Scandinavica·Ferhan EgilmezLippo V J Lassila
Sep 12, 2013·Connective Tissue Research·Ahmad TamjidipoorHasan Ahmadvand
Apr 12, 2014·Clinics in Geriatric Medicine·Joanna E M SaleEarl Bogoch
Jan 11, 2012·Orthopedics·John R Fowler, Matthew R Craig
Nov 10, 2012·International Endodontic Journal·A-T MoinzadehP R Wesselink
Nov 17, 2010·Dental Traumatology : Official Publication of International Association for Dental Traumatology·Sung Chul ChoiGue-Tae Kim
Oct 22, 2014·Journal of the American Geriatrics Society·Hanna C van der Jagt-WillemsWillem F Lems
Jan 29, 2014·The American Journal of Chinese Medicine·Chenrui LiQibing Mei
Feb 10, 2011·The Annals of Pharmacotherapy·Lee Cantrell, Mary Farson-Collier
Jul 4, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Guangwei ZhangEnqi Liu
Mar 24, 2016·Journal of Orthopaedic Trauma·John-David BlackWilliam G De Long
Jan 3, 2020·Journal of Bone and Mineral Metabolism·Kevin J FriesenJamie Falk
Dec 15, 2020·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Aleksandra Bitenc-JasiejkoDanuta Lietz-Kijak

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