Review of pemetrexed in combination with cisplatin for the treatment of malignant pleural mesothelioma.

Therapeutics and Clinical Risk Management
Ranjit K Goudar

Abstract

Malignant pleural mesothelioma is a resistant form of lung cancer, and its incidence continues to rise in Europe and Australia. Until recently, chemotherapy had not been shown to be effective in the treatment of this slowly progressive disease. In 2004, the combination of pemetrexed and cisplatin was shown to induce high response rates in MPM. This article reviews the published literature describing the development and testing of this therapeutic combination in mesothelioma, and examines in detail the key phase III clinical trial that led to the approval of pemetrexed by the US FDA. Ongoing research will further define the role of pemetrexed plus cisplatin in the treatment of MPM.

Citations

Feb 27, 2016·Oncotarget·Robert Fred Henry WalterFabian Dominik Mairinger
Sep 27, 2016·Expert Review of Anticancer Therapy·Bibhusal ThapaTom John
May 4, 2017·Virchows Archiv : an International Journal of Pathology·Fabian Dominik MairingerRobert Fred Henry Walter
Oct 7, 2017·Future Oncology·Navid SobhaniDaniele Generali
Nov 2, 2017·Journal of Clinical Pharmacy and Therapeutics·H CapelleM Montana
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