Review of phase I and II trials for Wilms' tumour - Can we optimise the search for novel agents?

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Jesper BrokFilippo Spreafico

Abstract

Survival rates for patients with Wilms' tumour (WT) approximate 90% with refined use of currently available interventions. However, a subgroup of patients, with initial high-risk histopathology or relapsing disease, have a poor prognosis, and it is a challenge to identify and prioritise the development of new innovative approaches for these subgroups. We conducted a systematic literature search for published phase I and II clinical trials that registered patients with WTs and characterised the early phase trial activity, quantified response rates and highlighted avenues for further development. We identified 63 trials (48 phase I, three phase I/II, and 12 phase II trials) enrolling 214 patients with WTs, alongside other malignancies. The number of annually recruited WTs did not change significantly and was less than 20% of the potential candidates. The vast majority of the trials were conducted in North America, and 56 different interventions were investigated, including conventional chemotherapy and biologically targeted therapies. Overall, 33 WTs revealed some degree of tumour control. Of these, five patients demonstrated complete remission (2%), 15 patients partial response (7%) and 13 patients stable disease (6%). None of t...Continue Reading

Citations

Jul 19, 2019·Experimental and Therapeutic Medicine·Yifeng Hu, Jingtie Yan
Sep 23, 2018·Human Genetics·Hildegard Nikki HallDavid R FitzPatrick
Aug 2, 2017·The Journal of Urology
Aug 21, 2019·Cells·João Victor da Silva GuerraMariana Maschietto
Jan 4, 2019·Paediatric Drugs·Radna Minou Oostveen, Kathy Pritchard-Jones
Feb 2, 2019·Nature Reviews. Nephrology·Taryn Dora TregerSam Behjati
Dec 21, 2020·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Jesper BrokFilippo Spreafico
Jun 12, 2021·Pediatric Blood & Cancer·Gemma GattaUNKNOWN JARC Pilot Study Toronto Guidelines Working Group
Oct 16, 2021·Nature Reviews. Disease Primers·Filippo SpreaficoKathy Pritchard-Jones

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European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Jesper BrokKathy Pritchard-Jones
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