Review of Saccharomyces boulardii as a treatment option in IBD

Immunopharmacology and Immunotoxicology
Kavitha Sivananthan, Andreas Munk Petersen

Abstract

Review of the yeast Saccharomyces boulardii as a treatment option for the inflammatory bowel diseases (IBD) ulcerative colitis and Crohn's disease. IBD is caused by an inappropriate immune response to gut microbiota. Treatment options could therefore be prebiotics, probiotics, antibiotics and/or fecal transplant. In this review, we have looked at the evidence for the yeast S. boulardii as a treatment option. Searches in PubMed and the Cochrane Library with the MeSH words 'Saccharomyces boulardii AND IBD', 'Saccharomyces boulardii AND Inflammatory Bowel Disease', 'Saccharomyces boulardii AND ulcerative colitis' and 'Saccharomyces boulardii AND Crohn's disease' gave total a total of 80 articles. After exclusions because of irrelevance, articles in other languages and some articles that were not available, 16 articles were included in this review. Three of the clinical trials showed a positive effect of S. boulardii in IBD patients (two Crohn's disease, one ulcerative colitis), while there was one trial that didn't prove any effect (Crohn's disease). Included Animal trials and cell assays describes different anti-inflammatory mechanisms of S. boulardii supporting a possible effect when treating IBD patients. The number of studies ...Continue Reading

References

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Citations

Jun 13, 2020·Expert Opinion on Therapeutic Patents·Farzin RoohvandNiloufar Kossari
Apr 27, 2019·Frontiers in Immunology·Renata CurciarelloCecilia Isabel Muglia
Dec 9, 2020·Journal of Applied Microbiology·Mayana Rodrigues S RibeiroMaria Aparecida Gomes
Jul 3, 2021·Nutrients·Leontien Depoorter, Yvan Vandenplas
Nov 28, 2021·International Journal of Molecular Sciences·Adi Eindor-AbarbanelKevan Jacobson

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