Review of studies concerning the tumorigenicity of 2-butoxyethanol in B6C3F1 mice and its relevance for human risk assessment

Journal of Toxicology and Environmental Health. Part B, Critical Reviews
Rodney BoatmanM M Udden

Abstract

The U.S. National Toxicology Program (NTP) has completed 2-yr inhalation exposures in rats and mice with 2-butoxyethanol (BE). This review concerns the most significant findings from those studies and describes recent research into the mechanistic aspects of BE-mediated tumorigenesis in the mouse and the relevance of such effects to humans. Two tumor types were increased in B6C3F1 mice leading to the classification of "some evidence" of carcinogenicity: liver hemangiosarcomas in male mice and forestomach tumors in female mice (primarily benign papillomas). The results of research collected to date indicate that the tumorigenesis noted for BE was produced by indirect mechanisms. In particular, the occurrence of liver hemangiosarcomas in male mice has been linked to oxidative damage subsequent to red blood cell hemolysis and iron deposition in this organ. Oral administration of BE in mice up to 600 mg/kg/d for up to 90 d produces a dose-related increase in iron (Perl's staining) in Kupffer cells and hepatocytes, increased DNA synthesis in endothelial cells, and enhanced oxidative damage. Further, iron alone, and not BE or BAA, is responsible for producing oxidative damage in cultured hepatocytes from rats or mice. Forestomach neo...Continue Reading

References

Aug 1, 1987·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J S Bus, J A Popp
Oct 1, 1986·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R Kroes, P W Wester
Nov 1, 1993·Human & Experimental Toxicology·F O OmaraL S Wanjala
Oct 1, 1993·Regulatory Toxicology and Pharmacology : RTP·J H McGeeR D Sofia
Jan 1, 1995·Archives of Toxicology·D V Sivarao, H M Mehendale
Dec 1, 1995·Toxicology Letters·J E KlaunigD E Stevenson
Aug 1, 1996·Regulatory Toxicology and Pharmacology : RTP·C F Wilkinson, J C Killeen
Dec 31, 1997·Mutation Research·B M Elliott, J Ashby
Sep 16, 1998·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R GingellS Lewis
Jun 22, 1999·Journal of Toxicology and Environmental Health. Part a·M F KhanG A Ansari
Sep 9, 1999·Toxicological Sciences : an Official Journal of the Society of Toxicology·E W CarneyW J Breslin
Jul 13, 2000·Human & Experimental Toxicology·B I GhanayemA Nyska
Jun 1, 2001·Zeitschrift für Rheumatologie·A A ShahinH M Gabr
Dec 12, 2001·Toxicology Letters·Joungjoa ParkJames E Klaunig
Jun 19, 2002·Blood·Andreas GoldammerMartin Haas
Jun 21, 2002·Toxicological Sciences : an Official Journal of the Society of Toxicology·Joungjoa ParkJames E Klaunig
Sep 7, 2002·Toxicological Sciences : an Official Journal of the Society of Toxicology·Mark M Udden
Nov 21, 2002·Toxicological Sciences : an Official Journal of the Society of Toxicology·Michael L Cunningham
Nov 21, 2002·Toxicological Sciences : an Official Journal of the Society of Toxicology·Angela M SieskyJames E Klaunig
Feb 4, 2003·Toxicological Sciences : an Official Journal of the Society of Toxicology·Torka S PoetRichard A Corley
Jan 28, 2004·Annual Review of Pharmacology and Toxicology·James E Klaunig, Lisa M Kamendulis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.