Review of Testim gel

Expert Opinion on Pharmacotherapy
Tom McNicholas, Teng Ong

Abstract

Hypogonadism is a medical condition characterised by testosterone deficiency in males, accompanied by numerous clinical symptoms, which can negatively affect quality of life and multiple organ systems. Late-onset hypogonadism describes testosterone deficiency or reduced effect seen in ageing men. The conditions are generally managed using testosterone supplementation. Many formulations of testosterone are available, including deep-muscle injections, buccal formulations, transdermal patches and topical gels. Testim gel 1% testosterone gel (Auxilium Pharmaceuticals, Inc. and Ipsen) has been shown to restore serum testosterone concentrations to within the normal range in men with hypogonadism. Two randomised, controlled studies showed that Testim gel significantly improved sexual motivation, desire, performance and function, as well as positive and negative mood scores and body composition after 90 days, compared with baseline. The magnitude of improvement seen with Testim gel was similar to that achieved with testosterone patches, but with fewer application-site reactions. In another study, improvements in mood and sexual function were seen within the first 2 weeks of treatment. Long-term, open-label extension studies of Testim g...Continue Reading

References

Oct 16, 1999·The Journal of Clinical Endocrinology and Metabolism·A VermeulenJ M Kaufman
Feb 22, 2002·BJU International·K SairamT A McNicholas
Dec 31, 2002·The American Journal of Psychiatry·Harrison G PopeJames I Hudson
Feb 13, 2003·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Stuart N Seidman
Jun 6, 2003·The Journal of Clinical Endocrinology and Metabolism·C SteidleUNKNOWN North American AA2500 T Gel Study Group
Aug 6, 2003·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·S Y KalinchenkoG V Katsiya
Sep 5, 2003·Journal of Andrology·Ka Kui LeeChristina Wang
Oct 4, 2003·BMJ : British Medical Journal·Stephen E Roberts, Michael J Goldacre
Nov 7, 2003·The Journal of Clinical Endocrinology and Metabolism·Sigrid von EckardsteinUNKNOWN International Committee for Contraception Research, The Population Council
Feb 7, 2004·The Journal of Clinical Endocrinology and Metabolism·John K AmoryJ Lisa Tenover
May 6, 2004·The Journal of Clinical Endocrinology and Metabolism·Márta KorbonitsAshley B Grossman

❮ Previous
Next ❯

Citations

Jan 29, 2014·Drug Design, Development and Therapy·M Iftekhar UllahChristian A Koch
Aug 8, 2012·Drugs·Katrina A Abadilla, Adrian S Dobs
Oct 17, 2012·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Bruno LunenfeldHeinrich M Schulte
Jun 25, 2009·The Journal of Sexual Medicine·Andre T GuayLaura A Offutt
Sep 1, 2014·Clinical Pharmacology in Drug Development·Håkan OlssonLars Grundemar
Jan 27, 2015·Best Practice & Research. Clinical Endocrinology & Metabolism·Eberhard Nieschlag
Mar 1, 2010·Expert Review of Endocrinology & Metabolism·Jo Anne B FarrellAli A Baghaie

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.