Review of the chemistry of alphaS2-casein and the generation of a homologous molecular model to explain its properties

Journal of Dairy Science
H M FarrellA Mora-Gutierrez

Abstract

alpha(S2)-Casein (alpha(S2)-CN) comprises up to 10% of the casein fraction in bovine milk. The role of alpha(S2)-CN in casein micelles has not been studied in detail in part because of a lack of structural information on the molecule. Interest in the utilization of this molecule in dairy products and nutrition has been renewed by work in 3 areas: biological activity via potentially biologically active peptides, functionality in cheeses and products, and nutrition in terms of calcium uptake. To help clarify the behavior of alpha(S2)-CN in its structure-function relationships in milk and its possible applications in dairy products, this paper reviews the chemistry of the protein and presents a working 3-dimensional molecular model for this casein. The model was produced by threading the backbone sequence of the protein onto a homologous protein: chloride intracellular channel protein-4. Overall, the model is in good agreement with experimental data for the protein, although the amount of helix may be over-predicted. The model, however, offers a unique view of the highly positive C-terminal portion of the molecule as a surface-accessible area. This region may be the site for interactions with kappa-carrageenan, phosphate, and othe...Continue Reading

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Citations

Aug 2, 2012·The Journal of Dairy Research·Maria ÅkerstedtMonika Johansson
May 6, 2010·The Biochemical Journal·Heath EcroydJohn A Carver
Mar 8, 2014·Andrologia·R AltintasA Beytur
Aug 14, 2012·Phytotherapy Research : PTR·Pavitra RanawatKrishan Lal Khanduja
Mar 27, 2015·Journal of Genetics·Xiaojun QuYing Ma
Jul 1, 2019·Comprehensive Reviews in Food Science and Food Safety·Chunyue ZhangKasper Hettinga
Jun 26, 2014·Journal of Agricultural and Food Chemistry·Valentin M RauhMarianne Hammershøj
Oct 29, 2019·The Journal of Physical Chemistry. a·Aleksandra M KusovaYuriy F Zuev
Feb 23, 2019·The Journal of Physical Chemistry. B·Daria L MelnikovaIrina V Nesmelova

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