Review of the clinical evidence for interferon beta 1a (Rebif) in the treatment of multiple sclerosis.

Neuropsychiatric Disease and Treatment
Francesco ManfredoniaFabio Monzani

Abstract

Interferon (INF) beta 1a 22 or 44 mug (Rebif((R))) administered s.c. 3 times a week (t.i.w) is a well established immunomodulating treatment for relapsing remitting multiple sclerosis (RRMS). This review focuses on its mechanisms of action, evidence of efficacy, safety, and tolerability. Several pharmacodynamic properties explain the immunomodulatory actions of INF beta 1a 22 or 44 mug s.c. t.i.w. Pivotal trials and post-marketing studies proved that the drug is effective in reducing disease activity and likely in slowing disease progression. Head-to-head comparative studies with other marketed INFs beta in RRMS suggested a better therapeutic response associated with higher doses and frequency of administration of Rebif((R)). Additional evidence indicated a beneficial effect of INF beta 1a in patients with clinically isolated syndromes (CIS) suggestive of MS, as treatment reduced time to conversion to clinically definite (CD) disease. Further, although the drug did not prove to slow time to progression there were benefits on relapse- and MRI-related secondary outcome measures in secondary progressive (SP) MS. Pivotal trials, their cross-over extensions, and post-marketing studies consistently showed that INF beta 1a 22 or 44 mu...Continue Reading

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Citations

Feb 15, 2014·Journal of Neuroinflammation·Luigi Maria Edoardo GrimaldiAndrea Paolillo
Mar 5, 2019·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Babak SoleimaniDavid Hunt
Mar 29, 2014·Physiological Measurement·Muhammad FarooqEdward Sazonov
Mar 22, 2018·Frontiers in Immunology·Cynthia LouisIan Wicks

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