Review of the combined contraceptive vaginal ring, NuvaRing.

Therapeutics and Clinical Risk Management
Frans Jme Roumen

Abstract

The purpose of this review was to test contraceptive efficacy, cycle control, tolerability, and acceptability as found in the non-comparative studies with NuvaRing((R)) by those found in the randomized trials comparing NuvaRing and combined oral contraceptives (COCs). All large non-comparative studies and all relevant randomized controlled trials (RCTs) between NuvaRing and a COC up to and including December 2006 were analyzed. Two large multi-center registration studies, 1 large daily clinical practice study, and 6 RCTs comparing NuvaRing and a COC were identified. The findings in the non-comparative studies were confirmed in the RCTs. Contraceptive efficacy was high showing no significant differences in comparison with the COC; cycle control was good and consistently better than that of the COC; compliance was high and comparable with that of the pill; the incidence of adverse events such as breast tenderness, headache, and nausea was low, but not lower than with the COC despite a halving of the systemic exposure to ethinyl estradiol (EE) with NuvaRing compared with a 30-mug EE-containing COC; the incidence of local and ring-related events was low but higher than with the COC, leading to higher discontinuation rates among Nuv...Continue Reading

Citations

Apr 17, 2015·BMC Public Health·Céline SchurmansUNKNOWN RING PLUS study group
Jun 19, 2018·PloS One·Evelyne KestelynUNKNOWN Ring Plus Study Group
Jan 27, 2019·Paediatrics & Child Health·Giuseppina Di MeglioJoanne Simms
Oct 30, 2010·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Gabriele S Merki-Feld, Martin Hund
May 28, 2011·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Johannes Bitzer
Sep 3, 2013·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Rossella E Nappi, UNKNOWN Italian Nuvaring Study Group
May 12, 2017·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Karen FreilichJane Fisher
Feb 25, 2020·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Patricio Barriga PooleyJorge López Berroa
Apr 18, 2017·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Elena MorottiCesare Battaglia
May 21, 2019·Perspectives on Sexual and Reproductive Health·Sara E VargasUNKNOWN other members of the Project WISH Research Team
Jan 1, 2018·Journal of Global Health Reports·Eleanor McLellan-LemalTaraz Samandari
Nov 9, 2019·Annals of Biomedical Engineering·Isabella ClaureJoyce Y Wong
Oct 22, 2013·BMC Women's Health·Txantón Martínez-Astorquiza-Ortiz de ZarateUNKNOWN MIA Study Investigators
Feb 9, 2016·Obstetrics and Gynecology·Amanda BoozalisJeffrey F Peipert
Jun 15, 2011·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Ahmed M M MohamedWalaa A I Mostafa
Mar 10, 2016·Journal of Sex Research·Jenny A Higgins, Nicole K Smith
May 28, 2019·Pharmaceutical Development and Technology·Veronika Nováková TkadlečkováPetr Poláček
May 14, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Elena MorottiCesare Battaglia
Jul 20, 2021·Geburtshilfe und Frauenheilkunde·Fojan RafieiKhosrow Mottaghy

❮ Previous
Next ❯

Methods Mentioned

BETA
contraception

Software Mentioned

NuvaRing

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.