Review of the contemporary cytotoxic and biologic combinations available for the treatment of metastatic breast cancer

Clinical Therapeutics
Katherine H Rak Tkaczuk

Abstract

Treatment of metastatic breast cancer (MBC) with > or =2 chemotherapeutic agents concurrently has been shown to increase response rates, often at the cost of a substantial increase in toxicity, and with minimal impact on the overall survival. However, some combinations of the newer cytotoxic agents, as well as combinations of chemotherapeutic agents and targeted biologic anticancer agents, can produce synergistic efficacy with a manageable toxicity profile. The aims of this work were to provide an overview of the currently approved combination regimens available for the treatment of MBC and to consider the clinical data supporting other drug combinations that may supplement the current therapeutic choices in the near future. Literature searches were performed using MEDLINE/PubMed, with a focus on combination therapies for the treatment of MBC that are approved by the US Food and Drug Administration (FDA) or in Phase III clinical trials. The National Institutes of Health's Clinical Trial Registry was searched for relevant ongoing clinical trials in specific areas. Bibliographies were also searched for additional relevant material. Preference was given to recently published, larger, well-designed clinical trials that influence cu...Continue Reading

References

Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·T C ChouS J Danishefsky
Jun 18, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Joyce O'ShaughnessyRobert Leonard
Aug 2, 2002·Breast Cancer Research and Treatment·Daniel R Budman, Anthony Calabro
Nov 7, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J-L MerlinN Bachmann
Feb 27, 2004·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Susan G Poole, Michael J Dooley
Apr 27, 2004·European Journal of Nuclear Medicine and Molecular Imaging·Valentina Guarneri, Pier Franco Conte
Nov 13, 2004·Breast Cancer Research : BCR·Freddie BrayD Maxwell Parkin
Nov 25, 2004·The Oncologist·Chantal Bernard-MartyMartine J Piccart
Feb 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kathy D MillerHope S Rugo
Sep 21, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·William J GradisharJoyce O'Shaughnessy
May 19, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Bhuvaneswari RamaswamyCharles L Shapiro
May 24, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·UNKNOWN American Society of Clinical Oncology
Jun 9, 2006·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S CinieriM Colleoni
Dec 29, 2006·The New England Journal of Medicine·Charles E GeyerDavid Cameron
Jun 5, 2007·Current Opinion in Oncology·Gary H Lyman, Michelle Shayne
Oct 13, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·T Fojo, M Menefee
Oct 31, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eva S ThomasHenri H Roché
Nov 13, 2007·Advances in Experimental Medicine and Biology·Ana Maria Gonzalez-AnguloGabriel N Hortobagyi
Nov 21, 2007·Clinical Breast Cancer·John S LinkCheryl I Jacobs
Dec 28, 2007·The New England Journal of Medicine·Kathy MillerNancy E Davidson
May 16, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D RaysonT Suter
May 30, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Blase N PoliteEric P Winer
Jul 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Erin R GardnerWilliam D Figg
Aug 2, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eleni Andreopoulou, Gabriel N Hortobagyi
Aug 20, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kathy S AlbainJoyce O'Shaughnessy
Dec 18, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·V RoyUNKNOWN North Central Cancer Treatment Group
Dec 18, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Francis Y F LeeRobert Kramer
Jan 14, 2009·Molecular Cancer Therapeutics·Charles DumontetFrancis F Y Lee
Jan 21, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P J Barrett-LeeM W Verrill
Mar 26, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Brian D RobinsonJoan G Jones
Apr 1, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Shelby D ReedKevin A Schulman

❮ Previous
Next ❯

Citations

Mar 2, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J J WhelerR Kurzrock
Mar 29, 2012·Advances in Urology·Marco A De Velasco, Hirotsugu Uemura
Apr 16, 2011·Breast Cancer : Basic and Clinical Research·Katherine H Rak Tkaczuk
Mar 13, 2014·International Journal of Molecular Sciences·Li-Xia FengNa Zhang
Jan 17, 2013·Translational Oncology·Benjamin A HoffCraig J Galbán
Aug 20, 2011·The Breast : Official Journal of the European Society of Mastology·E PlanchatX Durando
Mar 31, 2012·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·X F GuoB G Deng
Nov 9, 2010·Dermatologic Therapy·Vincenzo De GiorgiTorello Lotti
Jan 21, 2014·Biochimica Et Biophysica Acta·Juan Carlos Gallardo-PérezSara Rodríguez-Enríquez
Dec 18, 2013·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Shuhua DengXijing Chen
May 27, 2014·Biochemical and Biophysical Research Communications·Mellissa HicksJames DeWille
Jan 18, 2012·Chemotherapy·Ali I Shamseddine, Fadi S Farhat
May 18, 2010·Paediatric Anaesthesia·Gregory J Latham, Robert S Greenberg
Feb 27, 2010·Journal of Cancer Education : the Official Journal of the American Association for Cancer Education·Margaret RosenzweigKathleen Slavish
Mar 4, 2020·Diagnostics·Raúl Santiago-MonteroSergio Valadez-Godínez
Sep 26, 2012·International Journal of Molecular Medicine·Steven G GrayKenneth J O'Byrne
Aug 22, 2017·Journal of Controlled Release : Official Journal of the Controlled Release Society·Douglas R VogusSamir Mitragotri
Aug 1, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J J WhelerR Kurzrock
Jan 6, 2019·ACS Chemical Neuroscience·R GanugulaM N V Ravi Kumar
Dec 10, 2016·Analytical Chemistry·Heajin LeeJames N Wilson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.