Review of the Current Basic Science Strategies to Treat Critical Limb Ischemia

Vascular and Endovascular Surgery
Leila HaghighatCarlos I Mena-Hurtado

Abstract

Critical limb ischemia (CLI) is a highly morbid disease with many patients considered poor surgical candidates. The lack of treatment options for CLI has driven interest in developing molecular therapies within recent years. Through these translational medicine studies in CLI, much has been learned about the pathophysiology of the disease. Here, we present an overview of the macrovascular and microvascular changes that lead to the development of CLI, including impairment of angiogenesis, vasculogenesis, and arteriogenesis. We summarize the randomized clinical controlled trials that have used molecular therapies in CLI, and discuss the novel imaging modalities being developed to assess the efficacy of these therapies.

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Methods Mentioned

BETA
amputation
biopsies
imaging techniques

Clinical Trials Mentioned

NCT02538978
NCT03006770
NCT03174522
NCT03111238
NCT03423732
NCT01483898
NCT03042572

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