Review of the effects of anti-angiogenic compounds on the epiphyseal growth plate

Toxicologic Pathology
Anthony P HallPeter F Wadsworth

Abstract

The formation of new blood vessels from a pre-existing vascular bed, termed "angiogenesis," is of critical importance for the growth and development of the animal since it is required for the growth of the skeleton during endochondral ossification, development and cycling of the corpus luteum and uterus, and for the repair of tissues during wound healing. "Vasculogenesis," the de novo formation of blood vessels is also important for the proper function and development of the vascular system in the embryo. New blood vessel formation is a prominent feature and permissive factor in the relentless progression of many human diseases, one of the most important examples of which is neoplasia. It is for this reason that angiogenesis is considered to be one of the hallmarks of cancer. The development of new classes of drugs that inhibit the growth and proper functioning of new blood vessels in vivo is likely to provide significant therapeutic benefit in the treatment of cancer, as well as other conditions where angiogenesis is a strong driver to the disease process. During the preclinical safety testing of these drugs, it is becoming increasingly clear that their in vivo efficacy is reflected in the profile of "expected toxicity" (resul...Continue Reading

References

Jan 1, 1979·The Anatomical Record·B Meyrick, L Reid
Jan 1, 1992·Archives of Histology and Cytology·S PatanP H Burri
Oct 1, 1992·The Journal of Clinical Investigation·B F BoyceG R Mundy
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D J GoodN P Bouck
Jan 3, 1991·The New England Journal of Medicine·N WeidnerJ Folkman
Aug 1, 1990·Endocrinology·H S PhillipsN Ferrara
Jun 1, 1989·The Anatomical Record·R Baron
Jan 1, 1987·Virchows Archiv. A, Pathological Anatomy and Histopathology·M OsbornK Weber
Jan 1, 1972·Calcified Tissue Research·L I HanssonK G Thorngren
Jan 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·G GabbianiW W Franke
May 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·E D Frank, L Warren
Aug 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·F BreviarioE Dejana
May 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·C LoweP Soriano
Oct 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·F J Burrows, P E Thorpe
Jan 1, 1995·Human Pathology·S BiesterfeldA Böcking
Jul 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M AliniA R Poole
Feb 28, 1994·Biochemical and Biophysical Research Communications·V Midy, J Plouët
Feb 1, 1997·Endocrine Reviews·N Ferrara, T Davis-Smyth

❮ Previous
Next ❯

Citations

May 10, 2011·Cancer Chemotherapy and Pharmacology·Kenneth KolinskyBrian Higgins
Dec 27, 2011·Lymphatic Research and Biology·Karthik BalakrishnanJonathan A Perkins
Dec 7, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jennifer R DiamondGeoffrey I Shapiro
Aug 3, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·AeRang KimBrigitte C Widemann
Oct 6, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alberto BroniscerAmar Gajjar
Nov 2, 2011·The Oncologist·Julia Glade BenderElizabeth Fox
Mar 2, 2013·The Journal of Clinical Endocrinology and Metabolism·Maya B Lodish
Jan 31, 2016·Journal of Biomedical Materials Research. Part a·Adam Saltz, Umadevi Kandalam
Oct 26, 2011·Bone·Sunita Suri, David A Walsh
Apr 9, 2010·Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics·M Horvat-GordonR M Leach
May 7, 2008·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yumie RheeSung-Kil Lim
Sep 12, 2014·International Journal of Nephrology·Hassan Izzedine
Jan 12, 2010·Developmental Cell·Sally L Dunwoodie
Feb 21, 2013·Regulatory Toxicology and Pharmacology : RTP·Steve HornerRuth A Roberts
Mar 6, 2008·Journal of Pharmacological Sciences·Masaki KishiyaKen-Ichi Furukawa
Jun 12, 2016·Pharmacology & Therapeutics·Beverly L FalconBronislaw Pytowski
Oct 19, 2014·Toxicologic Pathology·A P HallK C Hickling
Jul 4, 2007·Veterinary Pathology·B YtrehusS Ekman
Aug 24, 2017·Tissue Engineering. Part B, Reviews·Nichole ShawKarin A Payne
Jun 24, 2017·Toxicologic Pathology·Kendall S Frazier
Oct 17, 2009·The Open Orthopaedics Journal·K D Evans, A M Oberbauer
Mar 6, 2019·Tissue Engineering. Part C, Methods·Sriveena SrinivasaiahUte Schäfer
May 8, 2019·Veterinary Pathology·Kristin OlstadEli Grindflek
Oct 1, 2009·Physiological Reviews·Carmen ClappGonzalo Martínez De La Escalera
Jul 12, 2018·Cell Death & Disease·Patricia Piñol-JuradoJordi Díaz-Manera
Sep 14, 2016·Journal of Toxicologic Pathology·Stacey FosseyJoel Leininger
Nov 13, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Christopher B EricksonKarin A Payne
Jan 13, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Anthony W TolcherMonica Mita
Jun 5, 2010·Chemical Research in Toxicology·Hisham K HamadehCynthia A Afshari

❮ Previous
Next ❯

Methods Mentioned

BETA
SMA
transgenic
xenograft

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.