Review of the molecular profile and modern prognostic markers for gastric lymphoma: how do they affect clinical practice?

Canadian Journal of Surgery. Journal Canadien De Chirurgie
Leonidas AlevizosGeorgios Zografos

Abstract

Primary gastric lymphoma is a rare cancer of the stomach with an indeterminate prognosis. Recently, a series of molecular prognostic markers has been introduced to better describe this clinical entity. This review describes the clinical importance of several oncogenes, apoptotic genes and chromosomal mutations in the initiation and progress of primary non-Hodgkin gastric lymphoma and their effect on patient survival. We also outline the prognostic clinical importance of certain cellular adhesion molecules, such as ICAM and PECAM-1, in patients with gastric lymphoma, and we analyze the correlation of these molecules with apoptosis, angiogenesis, tumour growth and metastatic potential. We also focus on the host-immune response and the impact of Helicobacter pylori infection on gastric lymphoma development and progression. Finally, we explore the therapeutic methods currently available for gastric lymphoma, comparing the traditional invasive approach with more recent conservative options, and we stress the importance of the application of novel molecular markers in clinical practice.

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Citations

Nov 16, 2013·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Miaoxia HeMinghua Zhu
Dec 17, 2014·Genomics, Proteomics & Bioinformatics·Shizhu ZangYouyong Lu
Feb 15, 2019·Circulation Research·Sandeep KumarHanjoong Jo
Apr 5, 2019·Irish Journal of Medical Science·Joshua De MarchiDermot Hehir
Oct 30, 2018·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Agustin AvilésNatividad Neri

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