Review on druggable targets of key age-associated properties regulated by therapeutic agents.

Chemical Biology & Drug Design
Ambili Unni PGirinath G Pillai

Abstract

Aging is a biological process which accounts for the deterioration of effective physiological functions. The malfunctioning of vital organ systems leads to the onset of neurodegenerative, cardiovascular, and immunomodulatory diseases in the elder population. Age-dependent mitochondrial dysfunctions trigger the production of reactive oxygen species, which serve as a major contributing factor for the onset of age-associated diseases. The increasing burden of age-related pathologies explicates the relevance of identifying novel therapeutic agents with enhanced potency and bioavailability. Key information on the biological mechanisms of significant age-related diseases aids in understanding relevant druggable targets essential for the initiation and progression of the disease. This review provides detailed insights into the druggable targets of key anti-aging properties of therapeutic agents such as anti-oxidant, immunomodulation, cardioprotection, anti-melanogenic, and anti-elastase properties. This information aids in the development of novel therapeutic agents/ supplements with enhanced efficacy.

References

Nov 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·K NakazonoM Inoue
Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M A NaviaK Hoogsteen
Nov 14, 1997·The New England Journal of Medicine·G J FisherJ J Voorhees
Oct 29, 2000·Experimental Gerontology·C FranceschiG De Benedictis
Jan 24, 2003·Nature·Ramanathan NateshK Ravi Acharya
Feb 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Daniela FrascaBonnie B Blomberg
Jul 23, 2004·Aging Cell·Stephen K Butcher, Janet M Lord
Jul 27, 2004·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·R M Touyz
Jan 1, 1995·Connective Tissue Research·B Starcher, M Conrad
Feb 9, 2006·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Feiko RijkenPiet L B Bruijnzeel
Jun 17, 2006·The EMBO Journal·Naotada IshiharaKatsuyoshi Mihara
Nov 3, 2006·Genes & Development·Marcia C Haigis, Leonard P Guarente
Apr 4, 2007·Cell Metabolism·Stefan M Schieke, Toren Finkel
Jan 15, 2008·Cellular and Molecular Life Sciences : CMLS·A SalminenK Kaarniranta
Jun 19, 2008·Genes & Development·Der-Fen SuenRichard J Youle
Jun 23, 2009·Biochimica Et Biophysica Acta·Monique N StanfelBrian K Kennedy
Dec 1, 2009·Clinics in Geriatric Medicine·Ali Yazdanyar, Anne B Newman
Jan 13, 2010·Experimental Gerontology·Martin D Brand
Jan 28, 2010·American Journal of Physiology. Endocrinology and Metabolism·Neil B RudermanYasuo Ido
Mar 13, 2010·The Journal of Pathology·Danielle GlickKay F Macleod
Mar 23, 2010·Cell·Carl Nathan, Aihao Ding
Apr 29, 2010·Current Hypertension Reports·Ana M Briones, Rhian M Touyz
Jul 30, 2010·Current Opinion in Immunology·Albert C ShawJanet M Lord
Oct 14, 2010·Journal of Cell Science·Arnold Y SeoChristiaan Leeuwenburgh
Nov 17, 2010·Pharmacological Reviews·Brice KorkmazFrancis Gauthier
Feb 22, 2011·Nature Cell Biology·Feng LiuJun Gu
Mar 25, 2011·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Antero SalminenKai Kaarniranta
Jul 13, 2011·International Journal of Hypertension·Agostino VirdisStefano Taddei
Sep 1, 2011·Handbook of Experimental Pharmacology·Akiko SatohShin Imai
Mar 14, 2012·Aging·Antero SalminenAnu Kauppinen
Jun 2, 2012·World Journal of Cardiology·Nikolaos LionakisMaria Georgopoulou

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