Review on multifaceted involvement of perivascular adipose tissue in vascular pathology

Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology
Olapoju Samuel O

Abstract

Perivascular adipose tissue (PVAT) is a fat tissue deposit that encircles the vasculature. PVAT is traditionally known to protect the vasculature from external stimuli that could cause biological stress. In addition to the protective role of PVAT, it secretes certain biologically active substances known as adipokines that induce paracrine effects on proximate blood vessels. These adipokines influence vascular tones. There are different types of PVAT and they are phenotypically and functionally distinct. These are the white and brown PVATs. Under certain conditions, white PVAT could undergo phenotypic switch to attain a brown PVAT-like phenotype. This type of PVAT is referred to as Beige PVAT. The morphology of adipose tissue is influenced by species, age, and sex. These factors play significant roles in adipose tissue mass, functionality, paracrine activity, and predisposition to vascular diseases. The difficulty that is currently experienced in extrapolating animal models to human physiology could be traceable to these factors. Up till now, the involvement of PVAT in the development of vascular pathology is still not well understood. Brown and white PVAT contribute differently to vascular pathology. Thus, the PVAT could be a t...Continue Reading

References

Jun 11, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·R J AielloP M Milos
Jun 2, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M BuyseM Lombès
Oct 30, 2001·The Proceedings of the Nutrition Society·P Trayhurn, J H Beattie
Aug 5, 2003·Journal of Lipid Research·Dominique LetexierMichel Beylot
Jan 6, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·D E Moller, J P Berger
May 25, 2004·Science·Saurabh D PatelLawrence Shapiro
Aug 5, 2004·The Journal of Clinical Endocrinology and Metabolism·Muredach P ReillyStephen E Kimmel
Jan 29, 2005·Endocrinology·Jérémie BoucherPhilippe Valet
Jan 4, 2007·The Journal of Clinical Investigation·Carey N LumengAlan R Saltiel
Apr 3, 2007·The Journal of Endocrinology·Chang-Jiang LiMei Zhang
Jan 17, 2008·Obesity·Ellen W DemerathBradford Towne
Jan 15, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Suparna M ChandraHyung J Chun
May 7, 2011·British Journal of Pharmacology·Gregory A PayneJohnathan D Tune
Jun 21, 2011·Clinical Lipidology·Kathryn A Britton, Caroline S Fox
Jul 14, 2011·American Journal of Physiology. Endocrinology and Metabolism·Norman E MillerKeith N Frayn
Sep 14, 2011·Clinical Science·Theodora Szasz, R Clinton Webb
Jun 9, 2012·Frontiers in Pharmacology·Beatriz Gálvez-PrietoMaria S Fernández-Alfonso
Jan 8, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Fiona M LynchAnthony M Heagerty
Jan 23, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Seojin KangJin-Ho Chung
Feb 1, 2014·Methods in Enzymology·Sebastian D ParleeOrmond A MacDougald
Feb 8, 2014·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Mabayoje A Oriowo
Feb 20, 2014·American Journal of Physiology. Endocrinology and Metabolism·Meritxell RosellMark Christian
Jul 12, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·Jean-Yves TanoMaik Gollasch
Mar 10, 2015·Scientific Reports·Elke AlbrechtSteffen Maak
May 27, 2015·International Journal of Molecular Sciences·Junyan XuGuo-Ping Shi
Apr 14, 2016·Stem Cells International·Miroslava CedikovaJitka Kuncova
Apr 23, 2016·International Journal of Obesity : Journal of the International Association for the Study of Obesity·K E ZaborskaC Austin
May 6, 2016·Frontiers in Endocrinology·Sung Sik ChoeJae Bum Kim
Jul 8, 2016·Adipocyte·María Calderon-DominguezLaura Herrero
Jan 8, 2017·British Journal of Pharmacology·Ryszard Nosalski, Tomasz J Guzik
Feb 6, 2017·British Journal of Pharmacology·M S Fernández-AlfonsoM R Dashwood
Mar 30, 2017·European Journal of Pharmacology·Andrea D van DamVanessa van Harmelen
May 16, 2017·Acta Pharmacologica Sinica·Shao-Wei SunJian-Xiong Chen

❮ Previous
Next ❯

Citations

Dec 4, 2020·Journal of Drug Targeting·Yin-Yu ZhangLi Qin
Dec 8, 2020·Frontiers in Cardiovascular Medicine·Ibrahim AlZaimAhmed F El-Yazbi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.