Review on pathogenicity mechanism of enterotoxigenic Escherichia coli and vaccines against it

Microbial Pathogenesis
Ali MirhoseiniShahram Nazarian

Abstract

Enterotoxigenic Escherichia coli (ETEC) is the most common cause of diarrhea in children. Colonization factors (CFs) and LT enterotoxin are the major ETEC candidate vaccines. To cause disease, ETEC must adhere to the epithelium of the small intestine by means of CFs. Watery diarrhea is produced due to the effects of the enterotoxins. Vaccine development against ETEC has been identified as an important primary prevention strategy in developing countries and for travelers to these regions. Mucosal immunization can cause secretory IgA antibody (sIgA) responses that prevents the attachment of bacteria to the intestine and are of particular importance for provide protection against ETEC infection. The design of multivalent ETEC vaccine containing various colonization factors and ETEC toxin may provide protection against a wide range of bacterial strains. In this review, the importance and pathogenesis of ETEC, and the latest ETEC vaccine research results are discussed.

Citations

Oct 12, 2019·Journal of Biophotonics·María B BallatoreEdgardo N Durantini
Oct 6, 2019·Applied and Environmental Microbiology·Angela Peña-GonzalezKonstantinos T Konstantinidis
Mar 27, 2020·Frontiers in Cellular and Infection Microbiology·Christian Rueter, Martina Bielaszewska
Aug 11, 2020·Current Opinion in Infectious Diseases·Kelsey J Jesser, Karen Levy
Oct 17, 2020·Journal of Photochemistry and Photobiology. B, Biology·Yohana B PalaciosAndrés M Durantini
Dec 10, 2020·Journal of Animal Science and Biotechnology·Johan S Osorio
May 4, 2021·Frontiers in Cellular and Infection Microbiology·Yunxia LiYulong Yin
Jul 9, 2021·Frontiers in Nutrition·Ayşenur ArslanSercan Karav
Jul 20, 2021·Advanced Drug Delivery Reviews·Chao PanHeng-Liang Wang
Sep 8, 2021·Frontiers in Cellular and Infection Microbiology·Mette ThorsingAnders Boysen

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