Review on the occasion of a decade of recombinant human TSH: prospects and novel uses

Thyroid : Official Journal of the American Thyroid Association
Leonidas H Duntas, David S Cooper

Abstract

The introduction of recombinant human thyroid-stimulating hormone (rhTSH) almost a decade ago represents a remarkable achievement in the history of clinical thyroidology. rhTSH now contributes substantially to the diagnostic approach to thyroid cancer, offering a reliable and safe alternative to thyroid hormone withdrawal by avoiding the morbidity of hypothyroidism. Several recent studies have also demonstrated the efficacy of radioiodine ablation of thyroid remnants after preparation with rhTSH. Moreover, the use of rhTSH in this context is associated with a lower whole body exposure to radiation compared to thyroid hormone withdrawal. Although not approved officially, rhTSH-assisted treatment of locoregional or distant metastatic disease may be the treatment of choice for patients in whom hypothyroidism may be relatively contraindicated, such as the very young and the aged, although additional efficacy studies are necessary. The compound has also been shown to be useful in the treatment of nontoxic multinodular goiter, especially when the radioiodine uptake is low. Finally, rhTSH may prove to be useful in studying the functional reserve of thyroid in the aging process, as well as the putative role of the TSH receptor in extra...Continue Reading

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Citations

Jul 14, 2009·Proceedings of the National Academy of Sciences of the United States of America·Susanne NeumannMarvin C Gershengorn
Jul 18, 2008·Thyroid : Official Journal of the American Thyroid Association·Bryan R HaugenFurio Pacini
May 17, 2011·Thyroid : Official Journal of the American Thyroid Association·Julia ReinfelderOlaf Prante
Feb 9, 2012·Thyroid : Official Journal of the American Thyroid Association·Joanna Klubo-GwiezdzinskaLeonard Wartofsky
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May 6, 2011·The Journal of Clinical Endocrinology and Metabolism·Rebecca S Bahn, M Regina Castro

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