REVIEW paper: pathophysiology of myocardial reperfusion injury: the role of genetically engineered mouse models

Veterinary Pathology
A RamachandranDavid J Lefer

Abstract

Coronary heart disease is the leading cause of death worldwide, affecting millions of men and women each year. Following an acute myocardial infarction, early and successful reperfusion therapy with thrombolytic therapy or primary percutaneous coronary intervention plays an important role in minimizing tissue injury associated with cessation of blood flow. The process of restoring blood flow to the ischemic myocardium, however, can induce additional injury. This phenomenon, termed myocardial ischemia-reperfusion (MI-R) injury, can paradoxically reduce the beneficial effects of myocardial reperfusion. MI-R injury is characterized by the formation of oxygen radicals upon reintroduction of molecular oxygen to the ischemic tissue, resulting in widespread lipid and protein oxidative modifications, mitochondrial injury, and cell death. In addition, studies have shown that MI-R is characterized by an inappropriate immune response in the microcirculation, resulting in leukocyte-endothelial cell interactions mediated by the upregulation of both leukocyte and endothelial cell adhesion molecules. Furthermore, MI-R ameliorates the production of certain cardioprotective factors such as nitric oxide. Advances in the generation of genetically...Continue Reading

References

Jun 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·P KubesD N Granger
Jan 1, 1971·Annals of Internal Medicine·W B KannelP M McNamara
Oct 22, 1993·Cell·D M HockenberyS J Korsmeyer
Oct 6, 1995·Science·C M KnudsonS J Korsmeyer
Oct 1, 1994·The Journal of Clinical Investigation·R A GottliebR L Engler
Sep 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J E SlighA L Beaudet
Jul 15, 1993·Biochemical and Biophysical Research Communications·V C PatelR G Woolfson
Sep 1, 1996·Circulation Research·R A KellyT W Smith
Nov 1, 1996·Circulation Research·H Fliss, D Gattinger
Jul 17, 1997·Nature·Q L DeverauxJ C Reed
Aug 1, 1997·Nature Genetics·C M Knudson, S J Korsmeyer
Sep 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·Z L ChuD W Ballard
Feb 12, 1998·The New England Journal of Medicine·A D Luster
Jan 23, 1999·Oncogene·J C Reed
Feb 17, 1999·Genes & Development·Q L Deveraux, J C Reed
Mar 17, 1999·Neuroscience Letters·M B BogdanovM F Beal
Mar 25, 1999·American Journal of Hypertension·D WangM C LaPointe
Aug 13, 1999·Genes & Development·A GrossS J Korsmeyer
Sep 2, 1999·Journal of Molecular and Cellular Cardiology·T A HollyV L Cryns
Sep 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·S D RobinsonR O Hynes
Dec 1, 1999·Cell Death and Differentiation·T S ZhengR A Flavell
Dec 28, 1999·Annual Review of Cell and Developmental Biology·I BudihardjoX Wang
Mar 31, 2000·Experimental Cell Research·T S Zheng, R A Flavell
Apr 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·K M KurrelmeyerD L Mann
Sep 21, 2000·The American Journal of Medicine·D J Lefer, D N Granger
Oct 25, 2000·American Journal of Physiology. Heart and Circulatory Physiology·S P JonesD J Lefer
Oct 26, 2000·Nature·M O Hengartner
Oct 31, 2000·Circulation Research·M R HoffmeyerD J Lefer

❮ Previous
Next ❯

Citations

Jun 8, 2012·Biochemistry Research International·Cécile MartelCatherine Brenner
Jun 27, 2012·Circulation·Nicholas J LeeperJohn P Cooke
Mar 24, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Claudia MedaEnrico Giraudo

❮ Previous
Next ❯

Methods Mentioned

BETA
coronary artery ligation
transgenic

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.