Review: Pharmacodynamic monitoring of immunosuppression in kidney transplantation

Nephrology
Katherine A BarracloughSteven J McTaggart

Abstract

Advances in immunosuppressive therapies have improved kidney transplant outcomes. However, immunosuppressant drug-induced toxicities continue to reduce tolerability and impact patient and graft survival. A major ongoing challenge in kidney transplantation is to establish ways of tailoring immunosuppressant therapy so as to maintain efficacy while minimizing toxicity. Pharmacodynamic monitoring by direct measurement of immune cell function has the potential to personalize immunosuppression. The purpose of this review is to provide the clinician with an overview of the methodology and use of immune function monitoring in the field of kidney transplantation.

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Citations

May 11, 2013·Case Reports in Infectious Diseases·Salvatore CocuzzaGiuseppe Nunnari
Jul 19, 2011·Journal of Transplantation·Katherine A BarracloughDavid W Johnson
Jan 14, 2012·Veterinary Surgery : VS·Kate HopperClare R Gregory
Mar 25, 2016·World Journal of Transplantation·Alberto Baroja-MazoJosé A Pons
Oct 27, 2015·Therapeutic Drug Monitoring·Eberhard Wieland, Maria Shipkova

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