Review: Reactive oxygen and nitrogen species and functional adaptation of the placenta.

Placenta
L Myatt

Abstract

The placenta regulates fetal growth and development via transport of nutrients and gases, and synthesis and secretion of steroid and peptide hormones. These functions are determined by vascular development and blood flow and by growth and differentiation of the trophoblast, which contains receptors, transporters and enzymes. The placenta generates reactive oxygen species which may contribute to the oxidative stress seen even in normal pregnancy but this is increased in pregnancies complicated by preeclampsia, IUGR and pregestational diabetes where oxidative and nitrative stress have been clearly documented. Nitrative stress is the covalent modification of proteins and DNA by peroxynitrite formed by the interaction of superoxide and nitric oxide. We have demonstrated nitrative stress by localizing nitrotyrosine residues in these placentas and found increased expression of NADPH oxidase (NOX) enzyme isoforms 1 and 5 as a potential source of superoxide generation. The presence of nitrative stress was associated with diminished vascular reactivity of the fetal placental circulation, a situation that could be reproduced by treatment with peroxynitrite in vitro. We find many nitrated proteins in the placenta, including p38 MAP kinase...Continue Reading

Citations

Mar 21, 2012·Reviews in Endocrine & Metabolic Disorders·Malgorzata S Martin-Gronert, Susan E Ozanne
Jun 10, 2011·Current Hypertension Reports·Catherine M Brown, Vesna D Garovic
May 1, 2013·Placenta·D BaczykJ C P Kingdom
Jun 18, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Dayane Teixeira OgnibeneAngela de Castro Resende
Oct 12, 2010·Nature·Aiwu ZhouRandy J Read
Jun 17, 2011·Antioxidants & Redox Signaling·Martha LappasAlicia Jawerbaum
Aug 1, 2012·Journal of Pregnancy·Loren P Thompson, Yazan Al-Hasan
Jun 7, 2013·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Marzena LaskowskaJan Oleszczuk
Jun 8, 2012·Environmental Health Perspectives·Kim BoekelheideJohn M Rogers
Jan 5, 2014·PloS One·Ramkumar MenonRobert N Taylor
Dec 4, 2012·International Journal of Molecular Sciences·Li-Tung HuangYou-Lin Tain
Feb 8, 2013·International Journal of Molecular Sciences·Xiao HuangChristiane Albrecht
Dec 12, 2013·European Journal of Clinical Nutrition·D WeberN Breusing
Dec 18, 2013·International Journal of Hygiene and Environmental Health·Iman Al-SalehAbdullah Rabbah
Dec 11, 2013·Reproduction : the Official Journal of the Society for the Study of Fertility·M A CostaG Correia-da-Silva
Jul 3, 2013·Reproduction : the Official Journal of the Society for the Study of Fertility·Michael J StarkNicolette A Hodyl
Aug 12, 2014·BioMed Research International·Felipe A ZunigaClaudio Aguayo
Apr 18, 2014·Antioxidants & Redox Signaling·Ludivine DoridotDaniel Vaiman
Jul 18, 2014·Cell Biology and Toxicology·Ana C Pereira, Fátima Martel
Aug 21, 2013·Human Reproduction Update·Régine P M Steegers-TheunissenKevin D Sinclair
May 23, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Cleofina BoscoRamón Rodrigo
Jul 12, 2011·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Dan MihuCarmen Mihaela Mihu
Jul 12, 2011·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Eleonora SalvoliniAndrea Luigi Tranquilli
Mar 5, 2015·International Journal of Molecular Sciences·Keiichi MatsubaraAkihiro Nawa
Sep 15, 2015·Systems Biology in Reproductive Medicine·Juvic M GoncalvesMaría I Camejo
Dec 7, 2013·Systems Biology in Reproductive Medicine·Petr ZolotukhinTatyana Shkurat
Sep 19, 2012·The Journal of Reproduction and Development·Masaharu MurataNorio Wake
Sep 3, 2014·Biomedical Journal·Daniel Vaiman
Jul 21, 2015·Obesity·Juan Manuel GallardoMiguel Klünder-Klünder
Jan 15, 2013·The Science of the Total Environment·Iman Al-SalehAbdullah Rabbah
Jul 17, 2012·Drug Discovery Today·Alfonso MateLuis Sobrevía
May 9, 2012·Reproductive Biomedicine Online·Estela BevilacquaAndrea M Amarante-Paffaro
Apr 3, 2012·Hormones and Behavior·Christopher L Howerton, Tracy L Bale

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basement Membranes

Basement membranes are thin, specialized extracellular matrices surrounding most tissues in all metazoans. Here is the latest research on basement membranes.

Related Papers

Best Practice & Research. Clinical Obstetrics & Gynaecology
G J Burton, E Jauniaux
Journal of the Society for Gynecologic Investigation
G J Burton, E Jauniaux
The American Journal of Pathology
Tereza Cindrova-DaviesD Stephen Charnock-Jones
© 2021 Meta ULC. All rights reserved