Review: role of tubal environment in preimplantation embryogenesis: application to co-culture assays

Zygote : the Biology of Gametes and Early Embryos
Pierre Guérin, Yves Ménézo

Abstract

The culture of early preimplantation stage embryo is still delicate and the metabolic pathways of embryos are not completely understood. Embryo needs are evolutionary during the preimplantation development, consequently it is difficult to meet embryo needs in vitro. Culture conditions have to respect several physical and chemical equilibria: such as redox potential, pH, osmotic pressure, metabolic flux of energetic compounds, endogenous pools of amino acids and transcripts, etc. Embryo culture media are generally supplemented with amino acids, glucose, other energetic metabolites and antioxidant compounds, vitamin, and growth factors etc. Furthermore autocrine and paracrine regulation of embryo development probably exist. In fact embryo culture conditions have to be as non-toxic as possible. Various types of co-culture systems have been devised to overcome these problems. Complex interrelations exist between embryos and co-cultured cells. The beneficial effects of co-cultured cells may be due to continuous modifications of the culture medium, i.e. the elimination of toxic compounds and/or the supply of embryotrophic factors.

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Citations

Jan 26, 2012·Journal of Assisted Reproduction and Genetics·Catherine M H CombellesCatherine Racowsky
Apr 15, 2014·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Chommanart ThongkittidilokMongkol Techakumphu
Dec 22, 2015·Methods : a Companion to Methods in Enzymology·David J LoganAnne E Carpenter
Jul 20, 2017·Molecular Reproduction and Development·Kailun Hu, Yang Yu

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