Review: Sperm-oocyte interactions and their implications for bull fertility, with emphasis on the ubiquitin-proteasome system

Animal : an International Journal of Animal Bioscience
P Sutovsky

Abstract

Fertilization is an intricate cascade of events that irreversibly alter the participating male and female gamete and ultimately lead to the union of paternal and maternal genomes in the zygote. Fertilization starts with sperm capacitation within the oviductal sperm reservoir, followed by gamete recognition, sperm-zona pellucida interactions and sperm-oolemma adhesion and fusion, followed by sperm incorporation, oocyte activation, pronuclear development and embryo cleavage. At fertilization, bull spermatozoon loses its acrosome and plasma membrane components and contributes chromosomes, centriole, perinuclear theca proteins and regulatory RNAs to the zygote. While also incorporated in oocyte cytoplasm, structures of the sperm tail, including mitochondrial sheath, axoneme, fibrous sheath and outer dense fibers are degraded and recycled. The ability of some of these sperm contributed components to give rise to functional zygotic structures and properly induce embryonic development may vary between bulls, bearing on their reproductive performance, and on the fitness, health, fertility and production traits of their offspring. Proper functioning, recycling and remodeling of gamete structures at fertilization is aided by the ubiquiti...Continue Reading

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Citations

Jun 9, 2018·Animal : an International Journal of Animal Bioscience·Michael G DiskinSean Fair
Oct 22, 2019·Frontiers in Cell and Developmental Biology·Tomer Avidor-ReissPuneet Sindhwani
Jan 21, 2021·Animals : an Open Access Journal From MDPI·Xin LiDong Wang
Apr 11, 2020·Animal Reproduction Science·Erdogan MemiliAbdullah Kaya

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