Review: The role of antibodies, autoantigens and food allergens in canine atopic dermatitis

Veterinary Dermatology
Cherie M Pucheu-HastonRosanna Marsella

Abstract

Canine atopic dermatitis (AD) is considered to be an immunoglobulin E (IgE)-mediated hypersensitivity response to environmental allergens. The role of other antibody isotypes and nonenvironmental allergens in disease pathogenesis remains unclear. The objective of this review is to provide an update on advances in the understanding of the relevance of specific antibody isotypes, autoallergens and nonenvironmental allergens in the pathogenesis of canine AD. Citation databases, abstracts and proceedings from international meetings published between 2001 and 2013 were reviewed. Where necessary, older articles were included for background information. Neither total nor allergen-specific IgE necessarily correlates with clinical disease in canine AD. Some dogs exhibit clinical signs that are indistinguishable from AD but have no demonstrable allergen-specific IgE (atopic-like dermatitis). Allergen-specific immunoglobulin G may be demonstrated in canine AD, but there is no evidence that this isotype plays a role in disease development. Although humans with AD may develop serum IgE against autoallergens, this finding has not been substantiated in the dog. In contrast, adverse food reactions are frequently co-associated with AD in the do...Continue Reading

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Citations

Jun 12, 2016·Veterinary Immunology and Immunopathology·Elizabeth A Layne, Douglas J DeBoer
Oct 21, 2016·Polish Journal of Veterinary Sciences·M FujimuraH Ishimaru
Dec 10, 2016·BMC Veterinary Research·Crystal R SundburgAnita M Oberbauer
Oct 24, 2017·Veterinary Sciences·Rosanna Marsella, Anna De Benedetto
Feb 5, 2021·Animals : an Open Access Journal From MDPI·Morena Di TommasoArianna Miglio
May 19, 2021·Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere·Amirhossein MohammaddavoodiRegina Wagner

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