Review: Time-space translation regulates trunk axial patterning in the early vertebrate embryo

Genomics
Antony J DurstonS Wacker

Abstract

Here, we review a recently discovered developmental mechanism. Anterior-posterior positional information for the vertebrate trunk is generated by sequential interactions between a timer in the early non-organiser mesoderm and the Spemann organiser. The timer is characterised by temporally colinear activation of a series of Hox genes in the early ventral and lateral mesoderm (i.e., the non-organiser mesoderm) of the Xenopus gastrula. This early Hox gene expression is transient, unless it is stabilised by signals from the Spemann organiser. The non-organiser mesoderm (NOM) and the Spemann organiser undergo timed interactions during gastrulation which lead to the formation of an anterior-posterior axis and stable Hox gene expression. When separated from each other, neither non-organiser mesoderm nor the Spemann organiser is able to induce anterior-posterior pattern formation of the trunk. We present a model describing that NOM acquires transiently stable hox codes and spatial colinearity after involution into the gastrula and that convergence and extension then continually bring new cells from the NOM within the range of organiser signals that cause transfer of the mesodermal pattern to a stable pattern in neurectoderm and thereby...Continue Reading

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Citations

Nov 21, 2013·Proceedings of the National Academy of Sciences of the United States of America·Antony J Durston
Jul 19, 2012·Annual Review of Cell and Developmental Biology·Lila Solnica-Krezel, Diane S Sepich
Apr 6, 2011·PloS One·Paul M J In der RiedenAntony J Durston
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Dec 14, 2011·Development, Growth & Differentiation·Lydia MichautWalter J Gehring
Aug 30, 2012·Developmental Dynamics : an Official Publication of the American Association of Anatomists·A J Durston
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Apr 26, 2019·Genesis : the Journal of Genetics and Development·Antony J Durston
Jan 16, 2021·ACS Synthetic Biology·Salva Duran-NebredaRicard Solé
Jun 24, 2010·Development·Paul François, Eric D Siggia
Jun 1, 2021·Interface Focus·Erik Clark

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