Reviewing the recommendations for lupus in children

Current Rheumatology Reports
Zehra Serap ArıcıSeza Ozen

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune connective tissue disorder with severe morbidity and mortality and diverse systemic involvement. Disease onset occurs during childhood in approximately 15 % of patients with SLE. It is important to treat the attacks adequately and prevent further flares for favorable long-term outcomes. The aim of effective disease management with early immunosuppression is to achieve symptomatic resolution and improvement in the quality of life by maintaining sustained remission and thereby preventing tissue damage. Adult literature on SLE management has evolved considerably over the past few decades based on observations from clinical studies investigating different immunosuppressive agents. We lack well-designed randomized controlled trials in children with SLE, thus we mainly depend on adult literature. Here, we review the literature for the current management of SLE in children and we present the recommendations and suggestions with the level of evidence.

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Citations

Nov 22, 2015·Expert Review of Clinical Immunology·Clovis Artur SilvaLucia Maria Arruda Campos
Jul 29, 2018·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Chien-Hung LinKuan-Yu Hung
Jan 6, 2016·Indian Journal of Pediatrics·Sujata Sawhney

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