PMID: 9524065Apr 2, 1998Paper

Revised definition of substrate binding sites of papain-like cysteine proteases

Biological Chemistry
D TurkB Turk

Abstract

A review of kinetic and structural data has enabled us to reconsider the definition of substrate binding sites in papain-like cysteine proteases. Only three substrate binding sites, S2, S1 and S1', involve main as well as side chain contacts between substrate and enzyme residues. Interactions between the enzymes and the substrate P3 and P2' residues are based on side chains (an exception is cathepsin B which is a carboxydipeptidase), so their interaction surface spreads over a relatively wide area. The location and definition of substrate binding sites beyond S3 and S2' is even more questionable.

References

Apr 1, 1992·Chemical & Pharmaceutical Bulletin·H KogaT Imoto
Sep 16, 1992·Biochemical and Biophysical Research Communications·C García-Echeverría, D H Rich
May 22, 1992·Biochimica Et Biophysica Acta·M SchusterH D Jakubke
Jun 9, 1992·Biochemistry·K I VarugheseN H Xuong
Feb 7, 1989·Biochemistry·K I VarugheseA C Storer
Apr 20, 1967·Biochemical and Biophysical Research Communications·I Schechter, A Berger
Oct 25, 1984·Journal of Molecular Biology·I G KamphuisJ Drenth
Nov 15, 1982·Journal of Molecular Biology·U HeinemannW Saenger
Aug 25, 1980·Journal of Molecular Biology·E N Baker
Jul 28, 1995·The Journal of Biological Chemistry·A TaralpS Hasnain
Sep 15, 1995·The Journal of Biological Chemistry·I DolencV Turk
Mar 24, 1995·Journal of Molecular Biology·M E McGrathR J Fletterick
Jan 1, 1994·Methods in Enzymology·N D Rawlings, A J Barrett
Jan 1, 1994·Methods in Enzymology·D J Buttle
Feb 17, 1995·Journal of Molecular Biology·P J Berti, A C Storer
Mar 1, 1994·Protein Engineering·K Brocklehurst
Dec 5, 1993·Journal of Molecular Biology·A Sali, T L Blundell
Aug 9, 1993·FEBS Letters·R MénardA C Storer
Jan 2, 1993·FEBS Letters·E SchröderC Crawford
Apr 26, 1993·FEBS Letters·H KakegawaN Katunuma
Jun 24, 1996·FEBS Letters·F AuthierJ J Bergeron
Aug 19, 1996·FEBS Letters·N A KaterelosR W Pickersgill
Dec 17, 1996·Biochemistry·D MaesY Looze
Jan 10, 1997·The Journal of Biological Chemistry·C IllyJ S Mort
Feb 1, 1997·Nature Structural Biology·M E McGrathD Brömme
Feb 1, 1997·Nature Structural Biology·B ZhaoS S Abdel-Meguid
Apr 21, 1997·FEBS Letters·A FujishimaT Sugawara
Aug 1, 1997·Protein Science : a Publication of the Protein Society·S A GillmorR J Fletterick

❮ Previous
Next ❯

Citations

Dec 21, 2006·Folia Microbiologica·A PavlovaC Gonzalez-Rey
Mar 26, 2004·Insect Biochemistry and Molecular Biology·Kristina GrudenMaarten A Jongsma
Aug 9, 2003·Biochemical Pharmacology·Deacon SweeneyThomas D Lockwood
Jul 19, 2002·Advances in Enzyme Regulation·Vito TurkJanko Kos
Jul 13, 2001·Antiviral Research·A Ruzindana-Umunyana, J M Weber
Feb 19, 2002·Molecular and Biochemical Parasitology·M Sajid, J H McKerrow
Nov 27, 1999·Bioorganic & Medicinal Chemistry Letters·P H DussaultT K Trullinger
Sep 27, 2003·European Journal of Biochemistry·Jeffrey P BocockAnn H Erickson
Sep 5, 2001·The EMBO Journal·V TurkD Turk
Aug 22, 2001·Protein Science : a Publication of the Protein Society·E Pol, I Björk
Feb 24, 2001·Protein Science : a Publication of the Protein Society·P M SmookerR N Pike
Jul 20, 1999·Annual Review of Biophysics and Biomolecular Structure·M E McGrath
May 21, 2010·PLoS Neglected Tropical Diseases·Jacob D DurrantJ Andrew McCammon
Jul 11, 2002·Biological Chemistry·Gilles LalmanachEdith Authié
Nov 13, 2010·Folia Histochemica Et Cytobiologica·Anil Kumar AgrawalMaciej Siewiński
Dec 6, 2012·Genetics and Molecular Research : GMR·A Soares-CostaF Henrique-Silva
Sep 15, 2011·Biochimica Et Biophysica Acta·Urška RepnikBoris Turk
Oct 26, 2011·Biochimica Et Biophysica Acta·Vito TurkDušan Turk
Aug 28, 2014·Future Medicinal Chemistry·Janko KosBojana Mirković
Sep 26, 2013·Genes & Development·Brian RuffellLisa M Coussens
Mar 23, 2010·Protein Engineering, Design & Selection : PEDS·Debi ChoudhuryJ K Dattagupta
Jun 5, 2012·Insect Biochemistry and Molecular Biology·Daniela BetonWalter R Terra

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.