Revisiting HIV-1 assembly

Médecine sciences : M/S
Antoine CorbinDelphine Muriaux

Abstract

During the late stage of virus replication, incorporation of the envelope glycoproteins (Env) by Gag cores takes place together with the proteolytic maturation of Gag and Gag-Pol precursors. Assembly is initially driven by Gag oligomerisation, which requires two platorms. The first one is formed by specific membrane subdomains with which Gag molecules interact via the N-terminal MA domain, and the second by the viral genomic RNA undergoing specific interactions with the NC domain of Gag. To complete viral budding, the Gag "late domain" subsequently associates with members of the ESCRT complexes involved in the budding of vesicles in late endosomes (LE). While the cellular trafficking of the viral components is still poorly understood, there is an ongoing debate on the site of HIV-1 assembly, because this process might take place either at the plasma membrane or in intracellular compartments such as the LE, depending on the virus/cell system studied. This site may depend on the interplay of multiple overlapping trafficking signals bear by Gag and Env. Our recent results indicate that it may rely on the chronic or acute nature of the viral infection more than on the cell type. In chronically infected cells, virions probably assem...Continue Reading

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Citations

Mar 10, 2011·Retrovirology·Elise Hamard-Peron, Delphine Muriaux
Jan 22, 2009·Médecine sciences : M/S·Erwan BeauchampPhilippe Legrand
Nov 29, 2008·Médecine sciences : M/S·Dominique Costagliola
Nov 29, 2008·Médecine sciences : M/S·Nolwenn Jouvenet
Jun 11, 2015·Médecine sciences : M/S·Julien BernaudCendrine Faivre-Moskalenko

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