Revisiting Oxycodone Analgesia: A Review and Hypothesis

Anesthesiology Clinics
Xiulu RuanAlan D Kaye

Abstract

Oxycodone, a semisynthetic opioid analgesic, is widely used in clinical practice. Oxycodone and morphine seem to be equally effective and equipotent; however, morphine is 10 times more potent than oxycodone when given epidurally. This article provides an updated review of the basic pharmacology of oxycodone with a special focus on pharmacokinetic/pharmacodynamics properties. The controversy regarding oxycodone-mediated effects for visceral pain via agonism and the possible role of peripheral opioid analgesia are discussed in the present investigation in an attempt to propose a plausible explanation to the perplexing question of oxycodone analgesia.

Citations

Mar 2, 2019·Current Pain and Headache Reports·Daniel RemillardHeath McAnally
Jan 18, 2019·Clinical Pharmacokinetics·Mari KinnunenMerja Kokki
Nov 28, 2020·Cellular and Molecular Neurobiology·Cherkaouia KibalyCatherine M Cahill
Jan 11, 2021·European Journal of Medical Research·Yan LiJun Ma

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