Revisiting pharmacology of oxidative stress and endothelial dysfunction in cardiovascular disease: Evidence for redox-based therapies.

Free Radical Biology & Medicine
Andreas Daiber, Stefan Chlopicki

Abstract

According to the latest Global Burden of Disease Study data, non-communicable diseases in general and cardiovascular disease (CVD) in particular are the leading cause of premature death and reduced quality of life. Demographic shifts, unhealthy lifestyles and a higher burden of adverse environmental factors provide an explanation for these findings. The expected growing prevalence of CVD requires enhanced research efforts for identification and characterisation of novel therapeutic targets and strategies. Cardiovascular risk factors including classical (e.g. hypertension, diabetes, hypercholesterolaemia) and non-classical (e.g. environmental stress) factors induce the development of endothelial dysfunction, which is closely associated with oxidant stress and vascular inflammation and results in CVD, particularly in older adults. Most classically successful therapies for CVD display vasoprotective, antioxidant and anti-inflammatory effects, but were originally designed with other therapeutic aims. So far, only a few 'redox drugs' are in clinical use and many antioxidant strategies have not met expectations. With the present review, we summarise the actual knowledge on CVD pathomechanisms, with special emphasis on endothelial dys...Continue Reading

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Citations

Aug 30, 2020·International Journal of Molecular Sciences·Nada A Sallam, Ismail Laher
Sep 15, 2020·Frontiers in Cell and Developmental Biology·Chen LiJianqiu Liang
Aug 13, 2020·Biomedicines·Jessica GambardellaValentina Trimarco
Apr 4, 2021·International Journal of Molecular Sciences·Rami S NajjarRafaela G Feresin
Apr 7, 2021·Journal of Medicinal Chemistry·Adriana AdamczykMalgorzata Baranska
Feb 28, 2021·Antioxidants & Redox Signaling·Jérémie Joffre, Judith Hellman
Apr 27, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Bartosz SkalskiBeata Olas
Mar 16, 2021·Redox Report : Communications in Free Radical Research·Stefanie S PortelliElizabeth N Robertson
May 20, 2021·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jamie E MeeganLorraine B Ware
Aug 10, 2021·Frontiers in Psychiatry·Alex J MurrayRachel Upthegrove
Apr 10, 2020·Free Radical Biology & Medicine·Maria Jesús Sanz, Maria José Alcaraz
Nov 16, 2021·International Reviews of Immunology·Azin AghamajidiNazanin Mojtabavi

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