Revisiting Polyarenes and Related Molecules: An Update of Synthetic Approaches and Structure-Activity-Mechanistic Correlation for Carcinogenesis

Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]
Dinabandhu SarDipanjan Pan

Abstract

A major proportion of basic cause for human cancer has been linked to widespread environmental pollutants including analogs of polyarenes. Search of an effective therapy can be started with the understanding of the generation of such "carcinogens" and their biological interactions. This review is to discuss the syntheses, structural activities, mechanistic and biological studies of polyarenes such as polycyclic aromatic hydrocarbons (PAHs), polycyclic azaarenes (PAAs) and their thia-analogs (PASH). It also summarizes the mechanism of mutagenicity and tumorigenicity via metabolic interventions producing diol epoxide complexes and eventually formation of DNA adducts. It suggests that inhibition of oxidative reactions and formation of diols and epoxides and unspecific intracellular activation of cytochrome P450 enzymes could be approaches in therapy against such mutagenicity and tumorigenicity. Thus, this review reflects that understanding of molecular mechanisms and activations along with a clinical and translational medicine approach would require achieving both prevention and treatment of this atrocity.

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·K M StraubM Calvin
Jun 1, 1978·Chemical & Pharmaceutical Bulletin·Y KitaharaT Sugimura
Jan 5, 1977·Journal of the American Chemical Society·K NakanishiI Weinstein
Sep 15, 1976·International Journal of Cancer. Journal International Du Cancer·M R OsborneP Brookes
Sep 14, 1992·Chemico-biological Interactions·E H WeyandE J LaVoie
Jan 1, 1990·Free Radical Biology & Medicine·J G Liehr, D Roy
Jul 1, 1988·Chemical Research in Toxicology·S C ChengA Dipple
Apr 1, 1988·Toxicology and Applied Pharmacology·R H BlantonP H Bick
Mar 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·K H VousdenD H Phillips
Jan 18, 1974·Science·D HoffmannE L Wynder
Sep 1, 1972·Journal of Medicinal Chemistry·J Pataki, R Balick
Dec 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·C B HugginsR G Harvey
Oct 24, 1995·Proceedings of the National Academy of Sciences of the United States of America·D ChakravartiE G Rogan
Jan 1, 1996·Annual Review of Biochemistry·A Sancar
Oct 6, 1997·Proceedings of the National Academy of Sciences of the United States of America·E L CavalieriE G Rogan
Feb 26, 1998·Chemical Research in Toxicology·J Szeliga, A Dipple
Oct 15, 1998·Carcinogenesis·A K KatzJ P Glusker
Jul 21, 1999·Journal of the National Cancer Institute·S S Hecht
Feb 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·Y PommierD M Jerina
Mar 4, 2000·Toxicological Sciences : an Official Journal of the Society of Toxicology·R BarhoumiR C Burghardt
Aug 30, 2000·Journal of the National Cancer Institute. Monographs·E CavalieriD Roy
Sep 1, 2000·Aquatic Toxicology· van Schanke AJ M Everaarts

❮ Previous
Next ❯

Citations

Nov 2, 2019·British Journal of Clinical Pharmacology·Fabrizio SchifanoAlessandro Vento

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.