Revisiting predictive biomarkers of musculoskeletal injury in thoroughbred racehorses: longitudinal study in polish population

BMC Veterinary Research
Agnieszka J TurloD D Frisbie

Abstract

High prevalence of musculoskeletal disorders in racehorses and its impact on horse welfare and racing economics call for improved measures of injury diagnosis and prevention. Serum biomarkers of bone and cartilage metabolism have previously shown promise in prediction of musculoskeletal injuries in horses. This study aimed to re-evaluate usability of the predictive serum biomarkers identified in North American Thoroughbred racehorses in a geographically distinct group of Polish Thoroughbreds. Serum concentrations of bone and cartilage biomarkers: osteocalcin, c-terminal telopeptide of type I collagen, total glycosaminoglycans (GAG), chondroitin sulfate epitope and c-propeptide of type II procollagen (CPII) were evaluated in the beginning and the next 3 months of one racing season in a cohort of twenty-six 2-year-old Polish racehorses. Exit criteria were diagnosis of musculoskeletal injury, leading to > 5 days off training (n = 8), or completion of 3 study months with no training interruptions (n = 18). Normalized results and matching archival data from 35 2-year-old North American racehorses was used for logistic regression analysis to identify universal predictors of injury. Mean GAG and CPII levels were lower in injured group...Continue Reading

References

Nov 1, 1991·Equine Veterinary Journal·H O MohammedJ Lowe
Jul 1, 1994·Equine Veterinary Journal·B J JohnsonJ Stoltz
Apr 30, 1998·Journal of the South African Veterinary Association·A OlivierA J Guthrie
Jan 10, 2001·Journal of the American Veterinary Medical Association·J HernandezM C Scollay
Apr 25, 2001·Journal of the American Veterinary Medical Association·A E HillA G Emerson
Oct 23, 2001·Research in Veterinary Science·J S PriceS W Ricketts
Oct 3, 2002·Equine Veterinary Journal·K MisumiS D Carter
Nov 27, 2002·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·I VervuertJ Harmeyer
Aug 24, 2006·Bone·Kristien VerheyenJames Wood
Mar 4, 2008·The Veterinary Clinics of North America. Equine Practice·Tim D H Parkin
Apr 30, 2008·Osteoarthritis and Cartilage·D D FrisbieC W McIlwraith
Jul 1, 2009·Equine Veterinary Journal·B F JacksonJ S Price
Mar 15, 2011·Osteoarthritis and Cartilage·V B KrausUNKNOWN OARSI FDA Osteoarthritis Biomarkers Working Group
Aug 25, 2011·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·C Wayne McIlwraithJ Richard Steadman
Oct 18, 2011·Journal of the American Veterinary Medical Association·Andrea L BeisserBryce Peckham
Jan 1, 2008·Journal of Equine Science·Yoshinobu InoueHideo Yano
Jun 18, 2017·Cartilage·Catherine B LegrandYves E Henrotin
Aug 29, 2018·Equine Veterinary Journal·A MitchellA E Watts

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Citations

Dec 1, 2019·Equine Veterinary Journal·Katie L EllisDavid D Frisbie
Jan 14, 2021·Equine Veterinary Journal·Allen E PageDavid W Horohov
Apr 4, 2021·Animals : an Open Access Journal From MDPI·Seungmee LeeSarah E Taylor

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Methods Mentioned

BETA
blood collection
ELISA

Software Mentioned

LOGISTIC

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