Revisiting the acute kidney injury in Wistar rats experimentally envenomated wity Bothrops jararacussu venom.

Toxicon : Official Journal of the International Society on Toxinology
Mayara A RomanelliLucienne S Lara

Abstract

There is no consensus on whether serotherapy prevents acute kidney injury (AKI) and there is no pharmacotherapy to impede the disease. We aimed to elaborate an AKI model induced by the administration of Bothrops jararacussu (Bj) venom for preclinical studies. Male Wistar rats were randomly divided into 3 different groups: (1) Bj-IV: intravenous administration of 0.4 mg/kg Bj; (2) Bj-IP: intraperitoneal administration of 2.0 mg/kg Bj; (3) Bj-IM: intramuscular administration of 3.5 mg/kg Bj. For each corresponding control group, a 0.9% saline solution was administered. Kidneys, blood and urine samples were collected 24 or 72 h after administration of the Bj venom for renal function analysis. The IV- and IP-Bj groups presented a moderate tubular injury (score 3) and a time-dependent kidney dysfunction. In the Bj-IM group, renal tubular injury was aggravated (score 4) with collagen deposition and renal dysfunction was observed in the first 24 h: hyperfiltration, proteinuria, albuminuria and decreased fractional sodium excretion (FENa), regardless of the administered dose. Over time, the glomerular lesion was intensified, with a decrease in glomerular filtration rate (GFR; 67%), blood urea-nitrogen (BUN; 68%) and urine volume decrea...Continue Reading

References

Jan 1, 1992·Toxicon : Official Journal of the International Society on Toxinology·E F SanchezC R Diniz
Jun 23, 1970·Biochemistry·S H FerreiraL J Greene
May 1, 1997·QJM : Monthly Journal of the Association of Physicians·R Milani JúniorD A Warrell
Aug 27, 1998·Hypertension·H YuJ L Garvin
May 8, 2001·Revista da Associação Médica Brasileira·F M Pinho, I D Pereira
Oct 16, 2001·Toxicon : Official Journal of the International Society on Toxinology·A HavtH S Monteiro
Oct 9, 2002·Toxicon : Official Journal of the International Society on Toxinology·P S F BarbosaH S A Monteiro
Mar 13, 2003·Kidney International·Giuseppe D'Amico, Claudio Bazzi
Apr 18, 2003·Cadernos de saúde pública·Rosany Bochner, Claudio José Struchiner
Aug 24, 2005·Toxicon : Official Journal of the International Society on Toxinology·P S F BarbosaH S A Monteiro
Oct 4, 2006·Nephrology·Visith Sitprija
May 1, 2007·Toxicon : Official Journal of the International Society on Toxinology·Noelson M V da SilvaPaulo A Melo
Nov 21, 2007·Toxicon : Official Journal of the International Society on Toxinology·Daniel N SifuentesPaulo A Melo
Jul 3, 2009·The New England Journal of Medicine·Xavier BoschJosep M Grau
Jul 22, 2014·Critical Care : the Official Journal of the Critical Care Forum·Nadezda Petejova, Arnost Martinek
Jun 21, 2015·Toxicon : Official Journal of the International Society on Toxinology·Rodrigo AyresLuis Eduardo M Quintas
Oct 11, 2017·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Aline L CortesLucienne S Lara
Aug 3, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Orsolya PéterfiLászló Bába
Jul 27, 2020·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Polianna Lemos Moura Moreira AlbuquerqueElizabeth De Francesco Daher

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