Revisiting the classification of adhesion GPCRs

Annals of the New York Academy of Sciences
Nicole ScholzTorsten Schöneberg

Abstract

G protein-coupled receptors (GPCRs) are encoded by over 800 genes in the human genome. Motivated by different scientific rationales, the two classification systems that are mainly in use, the ABC and GRAFS systems, organize GPCRs according to their pharmacological features and phylogenetic relations, respectively. Within those systems, adhesion GPCRs (aGPCRs) constitute a group of over 30 mammalian homologs, most of which are still orphans with undefined activating signals and signal transduction properties. Previous efforts have further subdivided mammalian aGPCRs into nine subfamilies to indicate phylogenetic relationships. However, this subclassification scheme has shortcomings and inconsistencies that require attention. Here, we have reassessed the phylogenetic relationships of aGPCRs from vertebrate and invertebrate species. Our findings confirm that secretin receptor-like GPCRs most probably emerged from ancestral aGPCRs. We show that reassignment of several aGPCRs to families essentially requires input from functional data. Our analyses establish the need for introducing novel aGPCR subfamilies due to aGPCR sequences from invertebrate species that are not readily assignable to any existing subfamily. We conclude that the...Continue Reading

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Citations

Jul 10, 2020·Neuro-oncology Advances·Joshua D FrensterDimitris G Placantonakis
Mar 19, 2021·Genesis : the Journal of Genetics and Development·Sarah BaxendaleTanya T Whitfield
May 8, 2021·Neuro-oncology Advances·Gabriele StephanDimitris G Placantonakis
Jun 11, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Noor Mazin AbdulkareemMeghana V Trivedi

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Methods Mentioned

BETA
biosensors
phylogenetic profile

Software Mentioned

ClustalW
BLASTing
dmCIRL
BioNJ
BLAST
MEGA7

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