Revisiting the effect compartment through timing errors in drug administration

Trends in Pharmacological Sciences
P NonyJ P Boissel

Abstract

The variations in the pharmacological effects induced by timing errors in drug intake are compared for two drugs, one acting by way of an effect compartment and the other directly from the central compartment. A simulation was performed for two drugs having the same concentration-effect relationship at the receptor site, the same mean effect at equilibrium and identical concentrations in the central compartment. In this article. Patrice Nony, Michel Cucherat and Jean-Pierre Boissel discuss how, for the same variability of concentrations in the central compartment, the variations in mean effects are different. When there is a large variability in the interval separating two consecutive doses, the model that includes an effect compartment dampens the pharmacokinetic variability present in the central compartment. Such an approach may be useful for the prescription recommendations of drugs, especially those with narrow therapeutic indices.

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Citations

Feb 5, 2002·Clinical Pharmacokinetics·Jean-Pierre Boissel, Patrice Nony
May 31, 2002·Clinical Pharmacokinetics·Patrice Nony, Jean-Pierre Boissel
Jan 23, 2003·Clinical Pharmacokinetics·Diane WongMurali Ramanathan
Jan 1, 2014·Orphanet Journal of Rare Diseases·Patrice NonyUNKNOWN Epi-CRESim
Jan 30, 2008·Journal of Clinical Epidemiology·Jean-Pierre BoisselAlain Leizorovicz
Mar 1, 2005·Basic & Clinical Pharmacology & Toxicology·Pascal Girard
Jun 16, 2004·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Iñaki F TrocónizWilly Roth
Jan 4, 2017·Expert Opinion on Drug Metabolism & Toxicology·Chiara PianaOscar Della Pasqua
Nov 23, 2007·Journal of Homosexuality·Bryan N CochranAna Mari Cauce
Jan 15, 2008·Journal of Ethnicity in Substance Abuse·Josefina AlvarezMargaret I Davis
Dec 25, 2019·Clinical Pharmacology and Therapeutics·Rishi J DesaiJoshua J Gagne
Mar 12, 2020·Thérapie·Patrice NonyUNKNOWN CRESim, Epi-CRESim research groups

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