Revisiting the metabolic syndrome: the emerging role of aquaglyceroporins

Cellular and Molecular Life Sciences : CMLS
Inês Vieira da SilvaGraça Soveral

Abstract

The metabolic syndrome (MetS) includes a group of medical conditions such as insulin resistance (IR), dyslipidemia and hypertension, all associated with an increased risk for cardiovascular disease. Increased visceral and ectopic fat deposition are also key features in the development of IR and MetS, with pathophysiological sequels on adipose tissue, liver and muscle. The recent recognition of aquaporins (AQPs) involvement in adipose tissue homeostasis has opened new perspectives for research in this field. The members of the aquaglyceroporin subfamily are specific glycerol channels implicated in energy metabolism by facilitating glycerol outflow from adipose tissue and its systemic distribution and uptake by liver and muscle, unveiling these membrane channels as key players in lipid balance and energy homeostasis. Being involved in a variety of pathophysiological mechanisms including IR and obesity, AQPs are considered promising drug targets that may prompt novel therapeutic approaches for metabolic disorders such as MetS. This review addresses the interplay between adipose tissue, liver and muscle, which is the basis of the metabolic syndrome, and highlights the involvement of aquaglyceroporins in obesity and related patholog...Continue Reading

References

Jul 1, 1976·Clinics in Endocrinology and Metabolism·J Hirsch, B Batchelor
Jan 1, 1987·Annual Review of Physiology·E Homsher
Apr 1, 1987·Diabetes/metabolism Reviews·R A DeFronzo, E Ferrannini
Sep 11, 1980·The American Journal of Physiology·J E HallT G Coleman
Dec 1, 1981·The Journal of Clinical Investigation·R A DeFronzoJ Wahren
Jan 1, 1997·Annual Review of Medicine·B B Lowell, J S Flier
Nov 14, 1997·The Journal of Physiology·H E MileyL Best
Feb 12, 1998·Biochemical and Biophysical Research Communications·H KuriyamaK Okubo
Aug 26, 1998·Biochimica Et Biophysica Acta·K IshibashiS Sasaki
Apr 25, 2000·The Journal of Biological Chemistry·K KishidaY Matsuzawa
Jun 6, 2000·American Journal of Physiology. Cell Physiology·B YangA S Verkman
Jun 1, 2001·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·D BrissonD Gaudet
Jun 20, 2001·American Journal of Hypertension·B M EganT L Goodfriend
Oct 27, 2001·The Journal of Biological Chemistry·K KishidaY Matsuzawa
Jan 16, 2002·JAMA : the Journal of the American Medical Association·Earl S FordWilliam H Dietz
Jan 16, 2002·American Journal of Human Genetics·C M LindgrenE S Lander
Mar 7, 2002·The Journal of Biological Chemistry·Tonghui MaA S Verkman
Apr 10, 2002·Circulation·Heinrich TaegtmeyerMartin E Young
Apr 16, 2002·European Journal of Biochemistry·Hidehiko KondoYuji Matsuzawa
Mar 11, 2003·American Journal of Physiology. Endocrinology and Metabolism·Guoqiang Jiang, Bei B Zhang
May 29, 2003·The Histochemical Journal·Yoshihiro WakayamaHiroaki Oniki
Jun 5, 2003·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·M FasshauerR Paschke
Oct 8, 2003·Journal of Molecular Biology·Bert L de GrootHelmut Grubmüller
Dec 13, 2003·The Journal of Clinical Endocrinology and Metabolism·Ruth J F LoosUNKNOWN HERITAGE Family Study
Feb 27, 2004·Cell and Tissue Research·Yoshihiro WakayamaHiroaki Oniki
Mar 26, 2004·Reviews in Endocrine & Metabolic Disorders·Martin Krssak, Michael Roden
Apr 10, 2004·American Journal of Physiology. Heart and Circulatory Physiology·James R Sowers
May 26, 2004·Endocrinology and Metabolism Clinics of North America·Gerald Reaven
Jul 10, 2004·Progress in Histochemistry and Cytochemistry·Kuniaki TakataYuki Tajika
Sep 2, 2004·Nature Reviews. Molecular Cell Biology·Landon S KingPeter Agre
Sep 16, 2004·Angewandte Chemie·Peter Agre
Dec 30, 2004·The Journal of Clinical Endocrinology and Metabolism·Kajsa SjöholmLena M S Carlsson
Jan 22, 2005·American Heart Journal·Phillippa J MirandaJohn R Guyton
Feb 11, 2005·Journal of Molecular Histology·A MobasheriD Marples
Apr 20, 2005·Lancet·Robert H EckelPaul Z Zimmet
Jul 13, 2005·Proceedings of the National Academy of Sciences of the United States of America·Toshiyuki HibuseIichiro Shimomura
Sep 13, 2005·Metabolism: Clinical and Experimental·Dae-Ho LeeMin-Young Chung
Oct 26, 2005·Biochemical Society Transactions·P Trayhurn, I S Wood

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Citations

Nov 15, 2018·Cells·Andreia F MóscaGraça Soveral
Oct 17, 2019·International Journal of Molecular Sciences·Tatjana ArsenijevicChristine Delporte
Jul 7, 2018·Frontiers in Chemistry·André GomesGraça Soveral
Jan 31, 2019·International Journal of Molecular Sciences·Chih-Yao HouLi-Tung Huang
Jan 23, 2020·International Journal of Molecular Sciences·Inês Vieira da SilvaGraça Soveral
Sep 19, 2019·American Journal of Physiology. Endocrinology and Metabolism·Shuyue WangYuxin Li
Jan 11, 2019·Digestive Diseases and Sciences·Shuyue WangHuiying Zhao
Nov 25, 2020·Cellular and Molecular Life Sciences : CMLS·Inês Vieira da SilvaGraça Soveral
Mar 11, 2021·Biochimie·Giuseppe Calamita, Christine Delporte
Jun 3, 2021·International Journal of Molecular Sciences·Agata Wawrzkiewicz-JałowieckaGraça Soveral
Jun 8, 2021·Biochimie·Inês V da SilvaGraça Soveral

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Methods Mentioned

BETA
X-ray

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