Revisiting the neural role of estrogen receptor beta in male sexual behavior by conditional mutagenesis

Hormones and Behavior
Lydie NauléSakina Mhaouty-Kodja

Abstract

Estradiol derived from neural aromatization of gonadal testosterone plays a key role in the perinatal organization of the neural circuitry underlying male sexual behavior. The aim of this study was to investigate the contribution of neural estrogen receptor (ER) β in estradiol-induced effects without interfering with its peripheral functions. For this purpose, male mice lacking ERβ in the nervous system were generated. Analyses of males in two consecutive tests with a time interval of two weeks showed an effect of experience, but not of genotype, on the latencies to the first mount, intromission, pelvic thrusting and ejaculation. Similarly, there was an effect of experience, but not of genotype, on the number of thrusts and mating length. Neural ERβ deletion had no effect on the ability of males to adopt a lordosis posture in response to male mounts, after castration and priming with estradiol and progesterone. Indeed, only low percentages of both genotypes exhibited a low lordosis quotient. It also did not affect their olfactory preference. Quantification of tyrosine hydroxylase- and kisspeptin-immunoreactive neurons in the preoptic area showed unaffected sexual dimorphism of both populations in mutants. By contrast, the numbe...Continue Reading

References

Feb 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·S OgawaD W Pfaff
Feb 12, 1998·Proceedings of the National Academy of Sciences of the United States of America·R B SimerlyK S Korach
Dec 11, 1997·Nature·R A HessD B Lubahn
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·J H KregeO Smithies
Jan 14, 1999·Endocrinology·A M van PeltG G Kuiper
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·S OgawaD W Pfaff
Oct 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·W KrezelP F Chapman
Dec 4, 2003·Hormones and Behavior·Jennifer L TempleEmilie F Rissman
Jun 10, 2004·Proceedings of the National Academy of Sciences of the United States of America·Otabek ImamovJan-Ake Gustafsson
Oct 30, 2004·Endocrinology·Trent D LundRobert J Handa
Mar 12, 2005·Proceedings of the National Academy of Sciences of the United States of America·Andrea E KudwaEmilie F Rissman
Jan 6, 2007·Endocrinology·Alexander S KauffmanManuel Tena-Sempere
Apr 20, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Alicia A WalfCheryl A Frye
Feb 13, 2008·Proceedings of the National Academy of Sciences of the United States of America·Maria Cristina AntalManuel Mark
Apr 24, 2008·The Journal of Steroid Biochemistry and Molecular Biology·Jaclyn M Schwarz, Margaret M McCarthy
Apr 10, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kalina RaskinSakina Mhaouty-Kodja
Feb 23, 2010·Journal of Neuroscience Methods·Melissa A SnyderCatherine S Woolley
Jul 2, 2010·The Journal of Comparative Neurology·Chitose Orikasa, Yasuo Sakuma
Nov 15, 2012·Proceedings of the National Academy of Sciences of the United States of America·Maria Cristina AntalAndrée Krust
Feb 15, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kathryn M LenzMargaret M McCarthy
Jan 10, 2014·The Journal of Endocrinology·Lydie NauléSakina Mhaouty-Kodja
Jul 30, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Heather A HendersonNathan A Fox
Aug 29, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Heather N LavezziDaniel S Zahm
Jan 13, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Giovanni HernandezPierre-Paul Rompré
Apr 15, 2015·The Journal of Endocrinology·Kushaan DumasiaN H Balasinor

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Citations

Mar 17, 2018·Médecine sciences : M/S·Daphné Capela, Sakina Mhaouty-Kodja
May 26, 2017·Physiological Reviews·Paul S CookeRex A Hess
Dec 14, 2019·The European Journal of Neuroscience·Badr KhbouzCharlotte A Cornil
Feb 16, 2018·Scientific Reports·Daphné CapelaSakina Mhaouty-Kodja
Feb 17, 2021·Médecine sciences : M/S·Lydie NauléSakina Mhaouty-Kodja
Oct 24, 2021·Frontiers in Neuroendocrinology·Arnaud JeanHélène Hardin-Pouzet

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