Revisiting the pathologic finding of diffuse alveolar damage after lung transplantation

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Masaaki SatoShaf Keshavjee

Abstract

Diffuse alveolar damage (DAD) is a non-specific pathologic diagnosis frequently encountered after lung transplantation. We examined the relationship between DAD and different forms of chronic lung allograft dysfunction (CLAD). We reviewed the results of 4,085 transbronchial biopsies obtained from 720 lung transplant recipients. DAD detected in biopsies within 3 months and newly detected DAD after 3 months were defined as early DAD and late new-onset DAD, respectively. Among patients with CLAD (FEV(1) <80% baseline), restrictive allograft syndrome (RAS) was defined by a decline in total lung capacity to <90% baseline and bronchiolitis obliterans syndrome (BOS) as CLAD without restrictive allograft syndrome (RAS). Kaplan-Meier analyses and multivariate proportional hazard models were used. DAD was observed in 320 of 720 (44.4%) patients at least once; early and late new-onset DAD were observed in 264 of 707 (37.3%) and 87 of 655 (13.3%) patients, respectively. Early DAD was associated with significantly higher 90-day mortality (20 of 264 [7.6%] vs 11 of 443 [2.5%]; p = 0.001). Moreover, among 502 bilateral lung transplant recipients who had sufficient pulmonary function tests to distinguish BOS and RAS, early DAD was associated w...Continue Reading

References

Feb 18, 2003·American Journal of Respiratory and Critical Care Medicine·Marc de PerrotShaf Keshavjee
May 12, 2004·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Heyman LuckrazJohn Wallwork
Dec 1, 2006·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Christopher M BurtonClaus B Andersen
Oct 9, 2007·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Bryan A WhitsonPeter S Dahlberg
Feb 12, 2008·Intensive Care Medicine·Claudia C Dos Santos
Aug 19, 2008·Seminars in Thoracic and Cardiovascular Surgery·Masaaki Sato, Shaf Keshavjee
Sep 13, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·H J HuangR R Hachem
Mar 23, 2011·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Masaaki SatoShaf Keshavjee

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Citations

Nov 10, 2012·General Thoracic and Cardiovascular Surgery·Masaaki Sato
Sep 29, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Efrat OfekDavid M Hwang
Apr 26, 2013·American Journal of Respiratory and Critical Care Medicine·Miranda ParaskevaGlen P Westall
Sep 26, 2013·American Journal of Respiratory and Critical Care Medicine·Michael Y ShinoJohn A Belperio
Jan 28, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Stijn E VerledenRobin Vos
Jul 3, 2013·The Annals of Thoracic Surgery·Pierre-Emmanuel Falcoz
Feb 26, 2013·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Masaaki SatoShaf Keshavjee
Dec 25, 2012·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Masaaki SatoShaf Keshavjee
Sep 8, 2015·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Tomohito SaitoShaf Keshavjee
Apr 23, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S HirayamaS Keshavjee
Oct 30, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·T SaitoS Keshavjee
Apr 11, 2015·Transplant International : Official Journal of the European Society for Organ Transplantation·Geert M VerledenStijn Verleden
Jan 13, 2015·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Stijn E VerledenRobin Vos
Dec 3, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Atul KapilaUNKNOWN AIRSAC investigators
May 6, 2016·Annals of the American Thoracic Society·Ariss DerHovanessianS Sam Weigt
Jun 4, 2016·Transplantation·Pierre-Joseph RoyerUNKNOWN SysCLAD consortium
Nov 1, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M Y ShinoJ A Belperio
Nov 12, 2016·Cell and Tissue Research·Mark KuehnelDanny Jonigk
Dec 23, 2016·Clinical Transplantation·Cristina BerasteguiAntonio Román
Mar 16, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S E VerledenM Greer
Jan 13, 2018·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jan H von der ThüsenStijn E Verleden
May 11, 2013·Current Pathobiology Reports·Amy P Wong, Janet Rossant
Jun 27, 2015·The European Respiratory Journal·Stijn E VerledenBart M Vanaudenaerde
Mar 19, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Stijn E VerledenDanny Jonigk
May 10, 2020·The European Respiratory Journal·Arno VanstapelUNKNOWN Leuven Lung Transplant Group
Nov 7, 2018·Der Pathologe·F LängerD Jonigk
Jan 9, 2021·Der Pathologe·Christopher WerleinDanny Jonigk
Mar 18, 2021·Pediatric Transplantation·Timothy KloudaLevent Midyat
May 25, 2021·Seminars in Respiratory and Critical Care Medicine·Olawale AmubieyaS Samuel Weigt
Apr 12, 2021·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Michael Y ShinoJohn A Belperio
Aug 28, 2021·World Journal of Transplantation·Metodija SekulovskiTsvetelina Velikova

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