Revisiting the Relationships Between Genomic G + C Content, RNA Secondary Structures, and Optimal Growth Temperature.

Journal of Molecular Evolution
Michelle M Meyer

Abstract

Over twenty years ago Galtier and Lobry published a manuscript entitled "Relationships between Genomic G + C Content, RNA Secondary Structure, and Optimal Growth Temperature" in the Journal of Molecular Evolution that showcased the lack of a relationship between genomic G + C content and optimal growth temperature (OGT) in a set of about 200 prokaryotes. Galtier and Lobry also assessed the relationship between RNA secondary structures (rRNA stems, tRNAs) and OGT, and in this case a clear relationship emerged. Increasing structured RNA G + C content (particularly in regions that are double-stranded) correlates with increased OGT. Both of these fundamental relationships have withstood test of many additional sequences and spawned a variety of different applications that include prediction of OGT from rRNA sequence and computational ncRNA identification approaches. In this work, I present the motivation behind Galtier and Lobry's original paper and the larger questions addressed by the work, how these questions have evolved over the last two decades, and the impact of Galtier and Lobry's manuscript in fields beyond these questions.

References

Jan 1, 1966·Cold Spring Harbor Symposia on Quantitative Biology·W SzybalskiP Sheldrick
Jul 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·J D KarkasE Chargaff
Jul 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·R RudnerE Chargaff
Jun 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·R RudnerE Chargaff
Sep 1, 1994·Nucleic Acids Research·Y Van de PeerR De Wachter
Jan 1, 1996·Nucleic Acids Research·M SprinzlS Steinberg
Dec 16, 1998·Journal of Molecular Evolution·M J McLeanK M Devine
Feb 26, 1999·Journal of Theoretical Biology·S J Bell, D R Forsdyke
Mar 16, 2000·Journal of Theoretical Biology·M Di Giulio
Nov 9, 2000·Molecular Biology and Evolution·G A Singer, D A Hickey
Jun 8, 2001·Bioinformatics·D Qi, A J Cuticchia
Sep 28, 2001·Nucleic Acids Research·R J CarterS R Holbrook
Apr 25, 2002·Nucleic Acids Research·Peter Schattner
May 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·Robert J KleinSean R Eddy
Aug 15, 2002·Bioinformatics·Pierre-François BaisnéePierre Baldi
Aug 21, 2002·Journal of Molecular Evolution·Hugo NayaHéctor Musto
Mar 19, 2003·Journal of Theoretical Biology·Massimo Di Giulio
Apr 15, 1962·Proceedings of the National Academy of Sciences of the United States of America·N SUEOKA
Aug 26, 2004·FEBS Letters·Héctor MustoGiorgio Bernardi
Sep 25, 2004·Nucleic Acids Research·Marie TouchonClaude Thermes
Oct 6, 2004·Genome Biology·Donal A Hickey, Gregory A C Singer
Dec 21, 2005·Biochemical and Biophysical Research Communications·David Mitchell, Robert Bridge
Feb 28, 2006·Biochemical and Biophysical Research Communications·Huai-Chun WangAndrew J Roger
Jul 4, 2006·Biochemical and Biophysical Research Communications·Héctor MustoGiorgio Bernardi
Nov 10, 2006·Proceedings of the National Academy of Sciences of the United States of America·Guenter Albrecht-Buehler
Mar 6, 2007·Biochemical and Biophysical Research Communications·Xiaoqian ZhaoJun Yu
Jun 15, 2007·BMC Genomics·Kohji OkamuraStephen W Scherer
Apr 19, 2008·PLoS Computational Biology·Jon BohlinDavid W Ussery
Nov 13, 2008·Proceedings of the National Academy of Sciences of the United States of America·Peter A Lind, Dan I Andersson
Nov 28, 2008·Nature·Bastien BoussauManolo Gouy
Jun 26, 2009·Journal of Molecular Evolution·Héctor RomeroHéctor Musto

❮ Previous
Next ❯

Citations

Feb 24, 2021·Journal of Molecular Evolution·Aaron D Goldman, David A Liberles
Nov 4, 2021·Proceedings of the National Academy of Sciences of the United States of America·Ming-Ling LiaoGeorge N Somero

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.