Revisiting the Role of Insulin-Like Growth Factor-I Receptor Stimulating Activity and the Apolipoprotein E in Alzheimer's Disease

Frontiers in Aging Neuroscience
Sara A GalleCornelia M van Duijn

Abstract

Background: Alterations in insulin-like growth factor I (IGF-I) signaling have been associated with dementia and Alzheimer's disease (AD). Studies on the association between IGF-I levels and dementia risk have been inconclusive. We reported earlier that higher levels of IGF-I receptor stimulating activity are associated with a higher prevalence and incidence of dementia. Objective: In the present study, we test the robustness of the association between IGF-I receptor stimulating activity and dementia by extending the follow-up period to 16 years and investigate possible effect modification by apolipoprotein E (ApoE). Methods: At baseline, circulating IGF-I receptor stimulating activity was determined by the IGF-I kinase receptor activation (KIRA) assay in 1,014 elderly from the Rotterdam Study. Dementia was assessed from baseline (1997-1999) to follow-up in January 2015. Associations of IGF-I receptor stimulating activity and incident dementia were assessed with Cox proportional hazards models. Results: During 10,752 person-years of follow-up, 174 people developed dementia. In the extended follow-up we no longer observed a dose-response relationship between IGF-I receptor stimulating activity and risk of dementia [adjusted odds...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Nov 1, 1994·Endocrinology·R R Reinhardt, C A Bondy
Apr 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·S DoréR Quirion
Apr 1, 1998·American Journal of Epidemiology·A OttA Hofman
Aug 28, 1998·Journal of Neural Transmission·L FrölichP Riederer
Jan 29, 1999·Journal of the National Cancer Institute·H YuX Wu
Feb 15, 2000·Annals of the New York Academy of Sciences·L FrölichS Hoyer
Mar 8, 2000·Brain Research Bulletin·W E SonntagJ K Brunso-Bechtold
Jun 27, 2002·Trends in Pharmacological Sciences·Laura GaspariniHuaxi Xu
Feb 27, 2003·American Journal of Physiology. Endocrinology and Metabolism·Jian-Wen ChenJan Frystyk
Apr 19, 2005·Brain Research Bulletin·Madeleine Le GrevèsFred Nyberg
Aug 27, 2005·Endocrinology·Clara M ChengCarolyn A Bondy
May 12, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tobias EngelJosé J Lucas
Dec 14, 2007·Biochemical Pharmacology·Thomas A LanzJoel B Schachter
Mar 5, 2008·Proceedings of the National Academy of Sciences of the United States of America·Yousin SuhPinchas Cohen
Apr 10, 2008·The Journal of Clinical Endocrinology and Metabolism·Michael P BrugtsJoseph A M J L Janssen
Nov 19, 2008·Neurology·J J SevignyUNKNOWN MK-677 Protocol 30 Study Group
Apr 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Eric M ReimanRichard J Caselli
Feb 27, 2010·Annals of Neurology·John C MorrisMark A Mintun
Dec 24, 2010·Neurobiology of Aging·Teo VargasEva Carro
Jan 10, 2013·Annual Review of Clinical Psychology·Shannon L Risacher, Andrew J Saykin
Jul 16, 2013·Alzheimer's Research & Therapy·Kristin R WildsmithGary E Landreth
Dec 5, 2013·Translational Psychiatry·A Trueba-SáizI Torres-Aleman
Feb 25, 2014·Neuron·Takahisa KanekiyoGuojun Bu
Apr 8, 2014·Journal of Alzheimer's Disease : JAD·Christopher J GreenYoav Ben-Shlomo
Apr 8, 2014·Neurology·Andrew J WestwoodSudha Seshadri

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Citations

Aug 3, 2019·Annals of Clinical and Translational Neurology·Emer R McGrathSudha Seshadri
Nov 7, 2019·Critical Reviews in Clinical Laboratory Sciences·Kirsten E J WesenhagenBetty M Tijms
Apr 23, 2020·Journal of Neurochemistry·Igor C FontanaEduardo R Zimmer
Jan 17, 2020·Current Pharmaceutical Design·Patricia Regina ManzineMarcia Regina Cominetti
May 12, 2020·Journal of Alzheimer's Disease : JAD·Gianmarco RosaUNKNOWN Disease Management Team on Dementia of the IRCCS Ospedale Policlinico San Martino (Genoa, I)
Sep 10, 2020·Journal of Personalized Medicine·Chiara ArgentatiSabata Martino
Jul 18, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Zahra SalehiMina Ohadi
Sep 8, 2019·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Joseph A M J L JanssenMichael P Brugts
Jan 23, 2021·Molecular Neurobiology·Sukhee ChoJinsoo Seo
Aug 18, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Madhunika AgrawalKanwaljit Chopra

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Methods Mentioned

BETA
transgenic

Software Mentioned

SPSS

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