Revisiting the Role of LXRs in PUFA Metabolism and Phospholipid Homeostasis

International Journal of Molecular Sciences
Antoine JalilDavid Masson

Abstract

Liver X receptors (LXRs) play a pivotal role in fatty acid (FA) metabolism. So far, the lipogenic consequences of in vivo LXR activation, as characterized by a major hepatic steatosis, has constituted a limitation to the clinical development of pharmacological LXR agonists. However, recent studies provided a different perspective. Beyond the quantitative accumulation of FA, it appears that LXRs induce qualitative changes in the FA profile and in the distribution of FAs among cellular lipid species. Thus, LXRs activate the production of polyunsaturated fatty acids (PUFAs) and their distribution into phospholipids via the control of FA desaturases, FA elongases, lysophosphatidylcholine acyltransferase (LPCAT3), and phospholipid transfer protein (PLTP). Therefore, LXRs control, in a dynamic manner, the PUFA composition and the physicochemical properties of cell membranes as well as the release of PUFA-derived lipid mediators. Recent studies suggest that modulation of PUFA and phospholipid metabolism by LXRs are involved in the control of lipogenesis and lipoprotein secretion by the liver. In myeloid cells, the interplay between LXR and PUFA metabolism affects the inflammatory response. Revisiting the complex role of LXRs in FA met...Continue Reading

References

Jul 12, 1996·The Journal of Biological Chemistry·T FujinoT Yamamoto
Apr 1, 1997·Proceedings of the National Academy of Sciences of the United States of America·M J KangT T Yamamoto
Nov 23, 2000·Genes & Development·J R SchultzB Shan
Jan 16, 2002·The Journal of Biological Chemistry·Sean B JosephPeter Tontonoz
Jul 31, 2002·Biochemical and Biophysical Research Communications·Takayuki Y NaraManabu T Nakamura
Aug 15, 2002·The Journal of Biological Chemistry·Guoqing CaoXian-Cheng Jiang
Aug 19, 2003·Journal of Lipid Research·Jeffrey W ChisholmRichard M Lawn
Jun 2, 2007·Circulation Research·Coralie FontaineGiulia Chinetti-Gbaguidi
Oct 22, 2008·Journal of Lipid Research·Hideo ShindouTakao Shimizu
Nov 22, 2008·Journal of Lipid Research·David MassonAlan R Tall
Jan 13, 2009·Biochimica Et Biophysica Acta·Yan QinHilde I Nebb
Dec 29, 2009·The Journal of Biological Chemistry·Hiroaki OkazakiGuosheng Liang
Sep 15, 2010·Gene·O DemeureS Lagarrigue
Jun 28, 2011·Biochimica Et Biophysica Acta·Un Ju JungRichard J Deckelbaum
May 24, 2013·Journal of Biochemistry·Hideo ShindouTakao Shimizu
Apr 4, 2015·Arteriosclerosis, Thrombosis, and Vascular Biology·Alexis VarinDavid Masson
Aug 29, 2017·The Journal of Clinical Investigation·Xin RongPeter Tontonoz
Jun 16, 2018·Nature Reviews. Endocrinology·Bo Wang, Peter Tontonoz
Nov 13, 2018·The New England Journal of Medicine·Deepak L BhattUNKNOWN REDUCE-IT Investigators

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Citations

Aug 6, 2020·International Journal of Molecular Sciences·Veronica D DahikWilfried Le Goff
Jul 19, 2020·BMC Gastroenterology·Jessica SeeßleUta Merle
Sep 5, 2020·International Journal of Molecular Sciences·Maria Fe LanfrancoG William Rebeck
May 1, 2021·Frontiers in Endocrinology·Inés Pineda-TorraElizabeth C Jury
Aug 8, 2021·International Journal of Molecular Sciences·Anna TkachevPhilipp Khaitovich

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Methods Mentioned

BETA
deacylation
lipidation

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