Revisiting the role of nanoparticles as modulators of drug resistance and metabolism in cancer

Expert Opinion on Drug Metabolism & Toxicology
Pranav GuptaZhe-Sheng Chen

Abstract

Drug resistance is the major obstacle impeding the efficacy of chemotherapeutic agents. Although numerous drug delivery techniques have been developed to combat drug resistance, their limitations of non-specific targeting and inconsistent bioavailability has led to the search of novel delivering strategies, such as nanoparticles. Nanoparticles for anti-cancer drug delivery are microscopic preparations encapsulating a chemotherapeutic and a chemosensitizer into a rationally designed drug delivery vehicle. Nano-strategies directed against multi-drug resistance (MDR) can be categorized into those inhibiting the drug efflux pumps, those effective against the cellular factors of drug resistance, and the combinational based strategies. Here, we review the most recent literature to reposition nanoparticles as chemotherapeutics and inhibitors of MDR. Novelty in anti-cancer drug delivery has led to the formulation of chemotherapeutics and MDR inhibitors as nano-preparations, which are multi-functional and have better tumor cell-targeting effects. Their characteristics of size and surface attachments make them readily diffusible through the tumor vasculature and increase their retention time as well. With a better understanding of the mo...Continue Reading

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Citations

Mar 8, 2017·Journal of Cellular Biochemistry·Pranav GuptaZhe-Sheng Chen
Feb 28, 2018·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Pranav GuptaZhe-Sheng Chen
Jan 16, 2019·International Journal of Molecular Sciences·Pranav GuptaZhe-Sheng Chen
Sep 9, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xitong SuPeng Zhang
Feb 6, 2021·Biomedical Materials·Yu ChenZhiyong Qian
Jul 30, 2021·Recent Patents on Anti-cancer Drug Discovery·Pranav GuptaZhe-Sheng Chen

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