Revisiting the vicious circle of dry eye disease: a focus on the pathophysiology of meibomian gland dysfunction

The British Journal of Ophthalmology
Christophe BaudouinMarc Labetoulle

Abstract

Meibomian gland dysfunction (MGD) is the most frequent cause of dry eye disease (DED). Eyelid inflammation, microbial growth, associated skin disorders as well as potentially severe corneal complications culminate to make MGD a complex multifactorial disorder. It is probable that MGD is a heterogeneous condition arising from any combination of the following five separate pathophysiological mechanisms: eyelid inflammation, conjunctival inflammation, corneal damage, microbiological changes and DED resulting from tear film instability. The pathogenesis of both MGD and DED can be described in terms of a 'vicious circle': the underlying pathophysiological mechanisms of DED and MGD interact, resulting in a double vicious circle. The MGD vicious circle is self-stimulated by microbiological changes, which results in increased melting temperature of meibum and subsequent meibomian gland blockage, reinforcing the vicious circle of MGD. Meibomian gland blockage, dropout and inflammation directly link the two vicious circles. MGD-associated tear film instability provides an entry point into the vicious circle of DED and leads to hyperosmolarity and inflammation, which are both a cause and consequence of DED. Here we propose a new pathophys...Continue Reading

References

Sep 1, 1993·Cornea·M NakamuraS Kinoshita
Dec 24, 1997·American Journal of Ophthalmology·O D ScheinS West
Jun 17, 1998·Ophthalmology·C A McCartyH R Taylor
Jul 1, 1999·Archives of Internal Medicine·O D ScheinS West
Mar 27, 2002·The British Journal of Ophthalmology·P J PisellaC Baudouin
Nov 24, 2004·Investigative Ophthalmology & Visual Science·De-Quan LiStephen C Pflugfelder
Oct 20, 2005·The British Journal of Ophthalmology·Y-Y GaoS C G Tseng
Nov 1, 2006·The Ocular Surface·James P McCulley, Ward E Shine
Nov 16, 2006·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Miki UchinoKazuo Tsubota
Nov 30, 2006·The Ocular Surface·Lenio S Alvarenga, Mark J Mannis
Dec 19, 2006·Cornea·Kaevalin LekhanontAnun Vongthongsri
Apr 10, 2007·Journal français d'ophtalmologie·C Baudouin
Feb 1, 2008·Investigative Ophthalmology & Visual Science·Zhuo ChenStephen C Pflugfelder
Apr 23, 2009·The Ocular Surface·Anthony J BronJohn M Tiffany
Sep 8, 2009·Experimental Eye Research·Chyong Jy NienJames V Jester
Nov 27, 2009·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·E Knop, N Knop
Feb 26, 2010·Investigative Ophthalmology & Visual Science·Louis TongRoger W Beuerman
Dec 21, 2010·Investigative Ophthalmology & Visual Science·Edoardo VillaniRoberto Ratiglia
Mar 15, 2011·Investigative Ophthalmology & Visual Science·Douglas BorchmanVictoria Greenstone
Mar 23, 2011·Investigative Ophthalmology & Visual Science·Rosa Maria CorralesStephen Carl Pflugfelder
Apr 1, 2011·Investigative Ophthalmology & Visual Science·Kelly K NicholsDavid A Sullivan
Apr 1, 2011·Investigative Ophthalmology & Visual Science·J Daniel NelsonGary N Foulks
Apr 13, 2011·Archives of Ophthalmology·Chyong Jy NienJames V Jester
Mar 20, 2012·Investigative Ophthalmology & Visual Science·Eloy VisoFrancisco Gude
Mar 21, 2012·Acta Ophthalmologica·Danuta I Kosik-BogackaElzbieta Kalisinska
Oct 17, 2012·Ophthalmology·Gary N FoulksJ Daniel Nelson
May 28, 2013·Journal français d'ophtalmologie·M Labetoulle, C Baudouin
Jun 14, 2013·Investigative Ophthalmology & Visual Science·Edoardo VillaniRoberto Ratiglia
Sep 18, 2013·Clinical Ophthalmology·Jing Qiao, Xiaoming Yan
Apr 4, 2014·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Yureeda QaziPedram Hamrah
Apr 29, 2014·Microbial Pathogenesis·Nathalia MurilloDidier Raoult
Jul 6, 2014·The British Journal of Ophthalmology·Paramdeep Singh BilkhuJames Stuart Wolffsohn
Dec 3, 2014·Journal français d'ophtalmologie·C Baudouin
Jan 13, 2015·Investigative Ophthalmology & Visual Science·Kara L MenziesLyndon Jones

❮ Previous
Next ❯

Citations

Sep 27, 2016·Journal of Cataract and Refractive Surgery·Ashiyana Nariani, Alan N Carlson
Dec 1, 2009·Progress in Retinal and Eye Research·E A GaffneyA J Bron
Jul 23, 2016·Indoor Air·P Wolkoff
Jun 7, 2017·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Julie M Albietz, Katrina L Schmid
Mar 11, 2017·International Ophthalmology Clinics·Perry Rosenthal
May 26, 2017·Clinical & Experimental Ophthalmology·Ji Won JungKyoung Yul Seo
Sep 29, 2017·Ophthalmology and Therapy·George W OuslerMark B Abelson
May 31, 2018·Expert Opinion on Pharmacotherapy·Konstadinos G Boboridis, Anastasios G P Konstas
Jun 4, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Michael-Adrien VitouxFrançoise Brignole-Baudouin
Sep 19, 2018·Acta Ophthalmologica·Marc LabetoulleJosé Benítez-Del-Castillo
Jan 11, 2019·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Kalaivarny GanesalingamJennifer P Craig
Jul 3, 2019·Antibiotics·Azadeh Tavakoli, Judith Louise Flanagan
Apr 26, 2017·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Nagayoshi AsanoKouichi Kawazu
Nov 19, 2019·Investigative Ophthalmology & Visual Science·Xiaojin DongYusen Huang
Dec 14, 2019·Eye & Contact Lens·Pun Yuet LamLouis Tong
Apr 18, 2020·Photobiomodulation, Photomedicine, and Laser Surgery·Dan LiBiao Cheng
Jan 14, 2019·The British Journal of Ophthalmology·Marc LabetoulleUNKNOWN DIDACTIC group
Oct 6, 2019·The British Journal of Ophthalmology·Lixing W RenekerAndrew J W Huang
Jun 27, 2020·Ocular Immunology and Inflammation·Samira HassanzadehAbbas Azimi Khorasani
Mar 16, 2017·Clinical & Experimental Ophthalmology·Stephanie Watson
Mar 16, 2017·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Hun LeeTae-Im Kim
Jun 9, 2017·Journal of Ophthalmology·Xiaolei LinYun-E Zhao
Jun 26, 2017·Biomedical Engineering Online·Robert KoprowskiPaweł Olczyk
Jun 24, 2020·International Journal of Molecular Sciences·Gysbert-Botho van Setten
Nov 15, 2017·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·C Auw-Hädrich, T Reinhard
Jan 8, 2019·F1000Research·Shruti Aggarwal, Anat Galor
Dec 29, 2018·Investigative Ophthalmology & Visual Science·Yureeda QaziPedram Hamrah
Feb 8, 2019·Eye·Edoardo Villani, Reiko Arita
Feb 6, 2020·Journal of Exercise Nutrition & Biochemistry·Bongkyun ParkChan-Sik Kim

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Methods Mentioned

BETA
confocal microscopy

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