Reward-circuit biomarkers of risk and resilience in adolescent depression

Journal of Affective Disorders
Adina S FischerIan H Gotlib

Abstract

Dysfunctional reward processing is a core feature of major depressive disorder. While there is growing knowledge of reward processing in adolescent depression, researchers have ignored neural mechanisms of resilience to depression. Here, we examine neural correlates of reward processing that characterize resilience and risk in adolescents at risk for depression, facilitating the development of effective intervention approaches that strengthen resilience to psychopathology in at-risk youth. 50 adolescent females were followed through age 18: 32 at-risk adolescents who either did (remitted-depressed; n = 15) or did not (resilient; n = 17) experience a depressive episode, and 18 low-risk healthy controls. Participants completed clinical assessments at 18-month intervals and an fMRI reward-processing task in late adolescence. We conducted predictive modeling with a priori reward regions of interest (ROIs). At-risk resilient and remitted-depressed adolescents exhibited less striatal activation than did controls during anticipation of reward. Resilient adolescents exhibited greater activation than did remitted-depressed adolescents in the middle frontal gyrus during reward anticipation, and less activation in the superior frontal gyr...Continue Reading

References

Feb 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·S VanniR Hari
Apr 3, 2001·Annual Review of Neuroscience·E K Miller, J D Cohen
Nov 15, 2001·NeuroImage·M W WoolrichS M Smith
Jan 22, 2003·Nature Neuroscience·Adam R AronTrevor W Robbins
Jun 24, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Gregor HaslerDennis S Charney
Sep 21, 2006·Brain : a Journal of Neurology·Foucaud du BoisgueheneucBruno Dubois
Feb 17, 2007·Acta Psychiatrica Scandinavica·S ZisookM Fava
Mar 7, 2007·Archives of General Psychiatry·Boadie W Dunlop, Charles B Nemeroff
Jan 30, 2008·Analytical and Bioanalytical Chemistry·Claudia Beleites, Reiner Salzer
Mar 11, 2008·Trends in Neurosciences·Susan L Andersen, Martin H Teicher
Apr 15, 2008·NeuroImage·Mark Woolrich
Dec 3, 2008·The American Journal of Psychiatry·Erika E ForbesRonald E Dahl
Apr 21, 2009·Lancet·Keith Hawton, Kees van Heeringen
Jun 17, 2009·Psychopharmacology·Ciara McCabeCatherine J Harmer
Jul 4, 2009·NeuroImage·Douglas N Greve, Bruce Fischl
Apr 7, 2010·Archives of General Psychiatry·Ian H GotlibJutta Joormann
Nov 26, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Susanne ErkHenrik Walter
Feb 7, 2012·Lancet·Anita ThaparAjay K Thapar
Aug 15, 2012·Trends in Cognitive Sciences·Mimi Liljeholm, John P O'Doherty
Dec 29, 2013·Developmental Cognitive Neuroscience·Thomas M OlinoErika E Forbes
Mar 27, 2016·Journal of the American Academy of Child and Adolescent Psychiatry·Katherine R LukingDeanna M Barch
May 2, 2016·Trends in Cognitive Sciences·Katherine R LukingDeanna M Barch
Jun 3, 2017·Social Cognitive and Affective Neuroscience·Natalie L ColichIan H Gotlib
Jun 21, 2018·The American Journal of Psychiatry·Hanna KerenArgyris Stringaris

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Citations

Jun 25, 2019·Journal of Child and Adolescent Psychopharmacology·Reem M A ShafiPaul E Croarkin
May 28, 2020·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Rajpreet ChahalAmanda E Guyer
Nov 25, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Adina S FischerLeanne M Williams
Oct 8, 2020·Current Opinion in Psychiatry·Adina S FischerIan H Gotlib
Aug 2, 2020·Journal of the American Academy of Child and Adolescent Psychiatry·Akua F NimarkoManpreet K Singh
Mar 25, 2021·Clinical Psychological Science : a Journal of the Association for Psychological Science·Steven W KasparekKatie A McLaughlin
Jul 28, 2021·Trauma, Violence & Abuse·Elizabeth R WattersArmeda S Wojciak
Aug 28, 2021·Journal of Research on Adolescence : the Official Journal of the Society for Research on Adolescence·Emily A HutchinsonCecile D Ladouceur

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