Reward, Control & Decision-Making in Cannabis Use Disorder: Insights from Functional MRI

The British Journal of Radiology
Hudaisa FatimaChristopher T Whitlow

Abstract

The recreational consumption of cannabis has increased significantly across the world with an estimated 180 million people currently using. In the United States, 4.1 million are currently diagnosed with cannabis use disorder. Cannabis dependence and abuse was combined into a single entity as a behavioral disorder with a problematic pattern of cannabis use and termed cannabis use disorder by the Diagnostic and Statistical Manual of Mental Disorders. Chronic use of cannabis has been linked with region-specific effects across the brain mediating reward processing, cognitive control and decision-making that are central to understanding addictive behaviors. This review presents a snapshot of the current literature assessing the effects of chronic cannabis use on human brain function via functional MRI. Studies employing various paradigms and contrasting cognitive activation amongst cannabis users and non-users were incorporated. The effects of trans-del-ta-9-tetrahydrocannabinol (Δ9-THC) in marijuana and other preparations of cannabis are mediated by the endocannabinoid system, which is also briefly introduced.Much variation exists in the current literature regarding the functional changes associated with chronic cannabis use. One p...Continue Reading

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Citations

Aug 20, 2019·The British Journal of Radiology·Amy L KotsenasJohn D Port
Mar 8, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Tonisha Kearney-Ramos, Margaret Haney
Aug 22, 2020·Current Opinion in Psychology·Emese KroonJanna Cousijn
Jul 16, 2021·Journal of the International Neuropsychological Society : JINS·Mackenzie B Taylor, Francesca M Filbey

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