Reward-dependent modulation of movement variability

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Sarah E PeknyReza Shadmehr

Abstract

Movement variability is often considered an unwanted byproduct of a noisy nervous system. However, variability can signal a form of implicit exploration, indicating that the nervous system is intentionally varying the motor commands in search of actions that yield the greatest success. Here, we investigated the role of the human basal ganglia in controlling reward-dependent motor variability as measured by trial-to-trial changes in performance during a reaching task. We designed an experiment in which the only performance feedback was success or failure and quantified how reach variability was modulated as a function of the probability of reward. In healthy controls, reach variability increased as the probability of reward decreased. Control of variability depended on the history of past rewards, with the largest trial-to-trial changes occurring immediately after an unrewarded trial. In contrast, in participants with Parkinson's disease, a known example of basal ganglia dysfunction, reward was a poor modulator of variability; that is, the patients showed an impaired ability to increase variability in response to decreases in the probability of reward. This was despite the fact that, after rewarded trials, reach variability in t...Continue Reading

Citations

Jan 1, 2016·Current Opinion in Neurobiology·Daniel M Wolpert, J Randall Flanagan
Jan 10, 2016·Brain : a Journal of Neurology·R Chris Miall, Joseph Galea
Jun 2, 2016·Proceedings of the National Academy of Sciences of the United States of America·Samuel D McDougleJordan A Taylor
Jun 9, 2016·Human Brain Mapping·Pradyumna SepulvedaSergio Ruiz
Sep 1, 2016·Frontiers in Neuroscience·Ioan OprisRandall J Nelson
Aug 31, 2016·PloS One·Volker Kast, Christian Leukel
Mar 18, 2017·Frontiers in Human Neuroscience·Niklas KönigNavrag B Singh
Jul 29, 2017·PLoS Computational Biology·Joshua G A CashabackPaul L Gribble
Nov 28, 2017·Frontiers in Human Neuroscience·Niklas König IgnasiakNavrag B Singh
Jul 1, 2017·Journal of Neurophysiology·Tony S L Wang, Joo-Hyun Song
Mar 15, 2018·Journal of Neurophysiology·Peter HollandJoseph M Galea
Mar 15, 2018·Journal of Neurophysiology·Erik M SummersideAlaa A Ahmed
Sep 28, 2017·Developmental Science·Mei-Hua LeeRajiv Ranganathan
May 2, 2018·Annual Review of Neuroscience·Ryan T Roemmich, Amy J Bastian
Mar 4, 2018·Annals of the New York Academy of Sciences·Floris T van Vugt, David J Ostry
Oct 26, 2018·Journal of Neurophysiology·Ananda SidartaDavid J Ostry
Mar 5, 2019·PLoS Computational Biology·Joshua G A CashabackPaul L Gribble
Feb 28, 2019·Journal of Neurophysiology·Dimitrios J PalidisPaul L Gribble
Jun 27, 2019·Journal of Neurophysiology·Shintaro UeharaPablo Celnik
Jan 18, 2020·Neural Computation·Tao BianZhong-Ping Jiang
Apr 3, 2020·PloS One·Nina M van MastrigtKatinka van der Kooij
Oct 30, 2018·Frontiers in Psychology·Teodora Gliga
May 10, 2019·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Matthew A CarlandPaul Cisek
Jan 14, 2016·Experimental Brain Research·K van der Kooij, K E Overvliet
May 11, 2017·Annual Review of Neuroscience·Ashesh K DhawaleBence P Ölveczky
Mar 8, 2018·PloS One·Katinka van der KooijJoeren B J Smeets
Aug 8, 2020·Frontiers in Behavioral Neuroscience·Mario TreviñoBelén Haro
Nov 10, 2017·The European Journal of Neuroscience·Welber MarinovicTimothy J Carroll
Jan 29, 2019·Frontiers in Applied Mathematics and Statistics·Corinne A JonesTimothy M McCulloch
Oct 30, 2020·PloS One·Simily SabuGünther Knoblich
Dec 2, 2020·ELife·Jing WangMehrdad Jazayeri
Jan 23, 2021·PloS One·Mario TreviñoRicardo Medina Coss Y León
May 17, 2017·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Lucio MarinelliMaria Felice Ghilardi
Jul 24, 2018·Current Opinion in Behavioral Sciences·Dagmar Sternad
May 27, 2021·Journal of Neurophysiology·Katrin SutterW Pieter Medendorp
May 27, 2021·Journal of Neurophysiology·Dimitrios J PalidisPaul L Gribble

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