Reward Network Immediate Early Gene Expression in Mood Disorders

Frontiers in Behavioral Neuroscience
Claire E ManningA J Robison

Abstract

Over the past three decades, it has become clear that aberrant function of the network of interconnected brain regions responsible for reward processing and motivated behavior underlies a variety of mood disorders, including depression and anxiety. It is also clear that stress-induced changes in reward network activity underlying both normal and pathological behavior also cause changes in gene expression. Here, we attempt to define the reward circuitry and explore the known and potential contributions of activity-dependent changes in gene expression within this circuitry to stress-induced changes in behavior related to mood disorders, and contrast some of these effects with those induced by exposure to drugs of abuse. We focus on a series of immediate early genes regulated by stress within this circuitry and their connections, both well-explored and relatively novel, to circuit function and subsequent reward-related behaviors. We conclude that IEGs play a crucial role in stress-dependent remodeling of reward circuitry, and that they may serve as inroads to the molecular, cellular, and circuit-level mechanisms of mood disorder etiology and treatment.

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Citations

May 14, 2019·Journal of Psychopharmacology·Carmelo MillónZaida Díaz-Cabiale
Apr 7, 2020·Journal of Psychopharmacology·Rachel-Karson ThériaultMelissa L Perreault
Apr 11, 2019·Molecular Psychiatry·Megan E Fox, Mary Kay Lobo
Aug 4, 2019·Neurochemical Research·Fatemeh RouhaniVahid Naseh
May 14, 2021·Frontiers in Genetics·Adrienne R HendersonTravis Dunckley

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Methods Mentioned

BETA
acetylation
transgenic
affinity purification

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