Reward responsiveness in patients with chronic pain

European Journal of Pain : EJP
Nicolas-Andreas ElvemoAsta Kristine Håberg

Abstract

It is proposed that changes in reward processing in the brain are involved in the pathophysiology of pain based on experimental studies. The first aim of the present study was to investigate if reward drive and/or reward responsiveness was altered in patients with chronic pain (PCP) compared to controls matched for education, age and sex. The second aim was to investigate the relationship between reward processing and nucleus accumbens volume in PCP and controls. Nucleus accumbens is central in reward processing and its structure has been shown to be affected by chronic pain conditions in previous studies. Reward drive and responsiveness were assessed with the Behavioral Inhibition Scale/Behavioral Activation Scale, and nucleus accumbens volumes obtained from T1-weighted brain MRIs obtained at 3T in 19 PCP of heterogeneous aetiologies and 20 age-, sex- and education-matched healthy controls. Anhedonia was assessed with Beck's Depression Inventory II. The PCP group had significantly reduced scores on the reward responsiveness, but not reward drive. There was a trend towards smaller nucleus accumbens volume in the PCP compared to control group. There was a significant positive partial correlation between reward responsiveness and...Continue Reading

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Citations

Jan 19, 2016·Frontiers in Psychology·Dan-Mikael EllingsenHåkan Olausson
Sep 1, 2016·Der Schmerz·S Becker, M Diers
Jan 21, 2017·Pain·Frank Porreca, Edita Navratilova
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Apr 14, 2017·European Journal of Pain : EJP·A K Håberg
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Aug 15, 2020·Frontiers in Psychology·Laura CasettaRaffaella Perrella
Jun 1, 2019·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Xinhe LiuFei Luo
May 10, 2018·Frontiers in Psychiatry·Amie L SeverinoWendy M Walwyn
Jan 5, 2021·Frontiers in Psychology·Laura Petrini, Lars Arendt-Nielsen
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Jan 28, 2021·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Patrick J HammettSteven S Fu
Feb 25, 2021·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Patrick H FinanKenzie L Preston

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