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Rewired signaling network in T cells expressing the chimeric antigen receptor (CAR)

bioRxiv

Dec 20, 2019

Rui DongXiaolei Su

Abstract

The chimeric antigen receptor (CAR) directs T cells to target and kill specific cancer cells. Despite the success of CAR T therapy in clinics, the intracellular signaling pathways that lead to CAR T cell activation remain unclear. Using CD19 CAR as a model, we report that, similar to th...read more

Mentioned in this Paper

IL2
Intracellular
Downstream
Signal Transduction Downstream of Smoothened
Tumor Cells, Malignant
Interleukin-2
T-Cell Receptor
T-Cell Activation
Antigens
T-Lymphocyte
8
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Rewired signaling network in T cells expressing the chimeric antigen receptor (CAR)

bioRxiv

Dec 20, 2019

Rui DongXiaolei Su

PMID: 990883496

DOI: 10.1101/2019.12.19.883496

Abstract

The chimeric antigen receptor (CAR) directs T cells to target and kill specific cancer cells. Despite the success of CAR T therapy in clinics, the intracellular signaling pathways that lead to CAR T cell activation remain unclear. Using CD19 CAR as a model, we report that, similar to th...read more

Mentioned in this Paper

IL2
Intracellular
Downstream
Signal Transduction Downstream of Smoothened
Tumor Cells, Malignant
Interleukin-2
T-Cell Receptor
T-Cell Activation
Antigens
T-Lymphocyte
8

Similar Papers Found In These Feeds

T cell Activation

T cell activation is a crucial checkpoint in adaptive immunity, and this activation depends on the binding parameters that govern the interactions between T cell receptors and peptide-MHC complexes. Here is the latest research.

BioRxiv Preprints

BioRxiv is the preprint server for biology, operated by Cold Spring Harbor Laboratory. Here are the latest biology preprint articles from bioRxiv.

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