Rewiring and regulation of cross-compartmentalized metabolism in protists.

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Michael L GingerP Michels

Abstract

Plastid acquisition, endosymbiotic associations, lateral gene transfer, organelle degeneracy or even organelle loss influence metabolic capabilities in many different protists. Thus, metabolic diversity is sculpted through the gain of new metabolic functions and moderation or loss of pathways that are often essential in the majority of eukaryotes. What is perhaps less apparent to the casual observer is that the sub-compartmentalization of ubiquitous pathways has been repeatedly remodelled during eukaryotic evolution, and the textbook pictures of intermediary metabolism established for animals, yeast and plants are not conserved in many protists. Moreover, metabolic remodelling can strongly influence the regulatory mechanisms that control carbon flux through the major metabolic pathways. Here, we provide an overview of how core metabolism has been reorganized in various unicellular eukaryotes, focusing in particular on one near universal catabolic pathway (glycolysis) and one ancient anabolic pathway (isoprenoid biosynthesis). For the example of isoprenoid biosynthesis, the compartmentalization of this process in protists often appears to have been influenced by plastid acquisition and loss, whereas for glycolysis several unexpe...Continue Reading

References

Jan 1, 1987·Annual Review of Biochemistry·P A Srere
Dec 2, 1985·European Journal of Biochemistry·E van SchaftingenH G Hers
Sep 1, 1981·European Journal of Biochemistry·N VisserP Borst
Jan 1, 1993·Progress in Biophysics and Molecular Biology·L A Fothergill-Gilmore, P A Michels
Jun 5, 1998·Trends in Biochemical Sciences·B TeusinkH V Westerhoff
May 18, 1999·The Journal of Biological Chemistry·B M BakkerH V Westerhoff
Sep 1, 1999·Proceedings of the National Academy of Sciences of the United States of America·B M BakkerH V Westerhoff
Feb 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·B M BakkerH V Westerhoff
Mar 15, 2000·Annals of Tropical Medicine and Parasitology·P A Phillips-Howard
Aug 6, 2000·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·N Heise, F R Opperdoes
Sep 6, 2000·Molecular Microbiology·Y Boucher, W F Doolittle
Jul 12, 2002·Cell Motility and the Cytoskeleton·Alistair HarrisonStephen M King
Oct 19, 2002·Proceedings of the National Academy of Sciences of the United States of America·Tetsuya FuruyaMarilyn Parsons
Nov 28, 2002·Journal of Lipid Research·Rainer Breitling, Skaidrite K Krisans
Mar 11, 2003·Antioxidants & Redox Signaling·Christine H Foyer, John F Allen
Nov 14, 2003·Kinetoplastid Biology and Disease·Véronique HannaertPaul AM Michels
Dec 31, 2003·Molecular Biology of the Cell·Javier Peña-DiazDolores Gonzalez-Pacanowska
Jan 20, 2004·Journal of Cell Science·Sietske HogenboomHans R Waterham
Jun 1, 1996·Annual Review of Plant Physiology and Plant Molecular Biology·William C. Plaxton
Apr 7, 2004·Molecular Microbiology·Yan BoucherW Ford Doolittle
Apr 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Guillaume MasséMichel Rohmer
Apr 15, 2004·Nature Reviews. Microbiology·Stuart A RalphGeoffrey I McFadden
Aug 17, 2004·The Biochemical Journal·Sundaramurthy VaradharajanGovindarajan Padmanaban
Nov 13, 2004·FEMS Microbiology Reviews·Juliette MoyersoenPaul A M Michels
Dec 25, 2004·Plant Physiology·Pablo LeivarXavier Fernàndez-Busquets
Feb 25, 2005·Nature·Brendan LoftusNeil Hall
Apr 30, 2005·Current Opinion in Plant Biology·Kirsten JørgensenBirger Lindberg Møller
Jun 11, 2005·Eukaryotic Cell·Charles HallFred S Dietrich
Jun 16, 2005·The Journal of Biological Chemistry·Marie-Astrid AlbertPaul A M Michels
Jul 7, 2005·The Journal of Cell Biology·Gregory J PazourGeorge B Witman

❮ Previous
Next ❯

Citations

Mar 18, 2010·Parasitology·Peter W CollingridgeMichael L Ginger
Feb 4, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Toni Gabaldón
Feb 4, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·William Martin
Feb 4, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Michael L GingerPaul A M Michels
Jun 13, 2012·Microbiology and Molecular Biology Reviews : MMBR·Miklós MüllerWilliam F Martin
Nov 22, 2015·The Plant Journal : for Cell and Molecular Biology·Joomi KimDesmond S Lun
Mar 30, 2013·Current Opinion in Chemical Biology·Mark HildebrandAubrey K Davis
Dec 7, 2011·International Journal for Parasitology·Melisa Gualdrón-LópezPaul A M Michels
Feb 14, 2012·Plant Science : an International Journal of Experimental Plant Biology·Martin LohrJürgen E W Polle
Mar 26, 2016·Molecular and Biochemical Parasitology·Somya Mani, Mukund Thattai
Sep 20, 2015·Biochimica Et Biophysica Acta·Jurgen R HaanstraPaul A M Michels
Dec 20, 2011·The Biochemical Journal·Craigen R NesW David Nes
Jul 24, 2012·Trends in Plant Science·Alison R TaylorGlen L Wheeler
Mar 8, 2013·Scientific Reports·Jae-Seong YangSanguk Kim
Apr 21, 2017·The Journal of Biological Chemistry·Casey L KohnhorstSongon An
Jan 24, 2015·Life·Bagmi Pattanaik, Pia Lindberg
Jul 20, 2018·Journal of Molecular Evolution·Abhishek Subramanian, Ram Rup Sarkar
Sep 25, 2010·Biochemical Society Transactions·Barbara M BakkerBas Teusink
Sep 3, 2019·Current Opinion in Genetics & Development·Cory D Dunn, Ville O Paavilainen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.